Reaction profile

The FDA adverse-event record for musculoskeletal neoplasm nos

70 FDA adverse-event reports reference musculoskeletal neoplasm nos (VeDDRA 1122). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1577 of 2,481
by report volume (all reactions)
70
reports citing this reaction
52.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Musculoskeletal neoplasm NOS has 70 reports now versus 69 in that prior snapshot: 1 more (1.4%).

Report change
+1
Death-coded reports
+1
Death-coded share
+0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Musculoskeletal neoplasm NOS changes

FDA AER · VeDDRA plate

Code 1122 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 70 reports
  • DEATH-HOT 52.9%
  • MID-PACK #1577/2481
  • PHOTO-FINISH Application site warm…
  • SPECIES-DOG Dog · 64
  • DRUG-LEAD Milbemycin Oxime… · 15
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site warmth (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Musculoskeletal neoplasm NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site warm… · near70Digestive tract hyper… · near70Hyporeflexia · near70Musculoskeletal neopl… · thi…70Saline slide agglutin… · near70Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Musculoskeletal neoplasm NOS

Musculoskeletal neoplasm NOS: high death-coded share in the FDA AER plate

Signature read: Musculoskeletal neoplasm NOS's 52.9% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 37 of 70 reports (52.9% of named reports). Nearest volume peer: Application site warmth (±0 reports). Lead species Dog (64). Lead co-reported drug Milbemycin Oxime + Spinosad (15).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 64
Cat 6

Breeds Most Affected

Retriever - Labrador 13
Retriever - Golden 7
Dog (unknown) 5
Crossbred Canine/dog 4
Greyhound 4
Domestic (unspecified) 3
Rottweiler 3
Shepherd Dog - German 3
Domestic Shorthair 3
Chihuahua 3

Associated Drugs

Milbemycin Oxime + Spinosad 15
Carprofen 12
Spinosad 6
Oclacitinib Maleate 6
Bedinvetmab 6
Trilostane 5
Grapiprant 4
Cyclosporine 3
Antibiotic 3
Gabapentin 3
Cefovecin Sodium 2
Ivermectin 2
Imidacloprid + Moxidectin 2
Cyclosporine A 2
Device: Surgical Instruments 2
Ivermectin + Pyrantel As Pamoate Salt 2
Afoxolaner 2
Milbemycin Oxime 2
Polysulfated Glycosaminoglycan 2
Glucosamine 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Musculoskeletal neoplasm NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (52.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Musculoskeletal neoplasm NOS (#1577 of 2,481 by report volume); death-coded 52.9%. PlainBreed reaction plate · death-coded share stamp 52.9% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →