Reaction profile

The FDA adverse-event record for musculoskeletal neoplasm nos

69 FDA adverse-event reports reference musculoskeletal neoplasm nos (VeDDRA 1122). See the species, breeds, and drugs most associated with it below.

69
reports citing this reaction
52.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
69
Total Reports
36
Deaths
52.2%
Death Rate

Species Most Affected

Dog 63
Cat 6

Breeds Most Affected

Retriever - Labrador 13
Retriever - Golden 7
Dog (unknown) 5
Crossbred Canine/dog 4
Greyhound 4
Domestic (unspecified) 3
Rottweiler 3
Shepherd Dog - German 3
Domestic Shorthair 3
Chihuahua 3

Associated Drugs

Milbemycin Oxime + Spinosad 15
Carprofen 11
Spinosad 6
Oclacitinib Maleate 6
Trilostane 5
Bedinvetmab 5
Grapiprant 4
Cyclosporine 3
Antibiotic 3
Cefovecin Sodium 2
Ivermectin 2
Imidacloprid + Moxidectin 2
Cyclosporine A 2
Device: Surgical Instruments 2
Ivermectin + Pyrantel As Pamoate Salt 2
Afoxolaner 2
Gabapentin 2
Milbemycin Oxime 2
Polysulfated Glycosaminoglycan 2
Glucosamine 2

Musculoskeletal neoplasm NOS Reaction Insights

69 reports name Musculoskeletal neoplasm NOS; 36 recorded a death outcome (52.2% of reported events, not a population-level mortality rate). VeDDRA code: 1122.

By species: Dog (63 reports), Cat (6 reports). By breed: Retriever - Labrador (13), Retriever - Golden (7), Dog (unknown) (5).

Most co-reported drugs: Milbemycin Oxime + Spinosad (15 reports), Carprofen (11 reports), Spinosad (6 reports), Oclacitinib Maleate (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.