Reaction profile

The FDA adverse-event record for vomiting bile

616 FDA adverse-event reports reference vomiting bile (VeDDRA 2758). See the species, breeds, and drugs most associated with it below.

616
reports citing this reaction
13.1%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
616
Total Reports
81
Deaths
13.1%
Death Rate

Species Most Affected

Dog 530
Cat 86

Breeds Most Affected

Domestic Shorthair 52
Retriever - Labrador 41
Crossbred Canine/dog 40
Retriever - Golden 29
Shih Tzu 26
Chihuahua 25
Dog (unknown) 21
Terrier - Yorkshire 19
Shepherd Dog - Australian 16
Maltese 15

Associated Drugs

Afoxolaner 61
Bedinvetmab 55
Maropitant Citrate 52
Pyrantel Pamoate;Sarolaner 51
Fluralaner 13.64% 12-Week Chew 44
Ivermectin + Pyrantel As Pamoate Salt 39
Milbemycin Oxime + Praziquantel 35
Carprofen 30
Lotilaner 27
Moxidectin 22
Milbemycin Oxime + Spinosad 21
Unspecified 20
Trilostane 18
Gabapentin 16
Grapiprant 16
Praziquantel + Pyrantel Pamoate 14
Oclacitinib Maleate 13
Metronidazole 13
Enrofloxacin 13
Pimobendan 13

Vomiting bile Reaction Insights

616 reports name Vomiting bile; 81 recorded a death outcome (13.1% of reported events, not a population-level mortality rate). VeDDRA code: 2758.

By species: Dog (530 reports), Cat (86 reports). By breed: Domestic Shorthair (52), Retriever - Labrador (41), Crossbred Canine/dog (40).

Most co-reported drugs: Afoxolaner (61 reports), Bedinvetmab (55 reports), Maropitant Citrate (52 reports), Pyrantel Pamoate;Sarolaner (51 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.