Reaction profile

The FDA adverse-event record for inappropriate defecation

2,084 FDA adverse-event reports reference inappropriate defecation (VeDDRA 123). See the species, breeds, and drugs most associated with it below.

2,084
reports citing this reaction
12.8%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
2,084
Total Reports
267
Deaths
12.8%
Death Rate

Species Most Affected

Dog 1,761
Cat 320
Horse 2
Cattle 1

Breeds Most Affected

Domestic Shorthair 200
Retriever - Labrador 179
Crossbred Canine/dog 108
Chihuahua 82
Shih Tzu 78
Shepherd Dog - German 70
Terrier - Yorkshire 66
Retriever - Golden 66
Maltese 46
Beagle 46

Associated Drugs

Afoxolaner 224
Milbemycin Oxime + Spinosad 212
Ivermectin + Pyrantel As Pamoate Salt 144
Bedinvetmab 133
Fluralaner Chew Tablets 111
Moxidectin 106
Spinosad 81
Milbemycin Oxime + Praziquantel 78
Carprofen 77
Maropitant Citrate 77
Pyrantel Pamoate;Sarolaner 73
Gabapentin 68
Trilostane 59
Oclacitinib Maleate 55
Imidacloprid + Moxidectin 50
Sarolaner 45
Fluralaner 13.64% 12-Week Chew 45
Prednisone 42
Nitenpyram 42
Selamectin 41

Inappropriate defecation Reaction Insights

2,084 reports name Inappropriate defecation; 267 recorded a death outcome (12.8% of reported events, not a population-level mortality rate). VeDDRA code: 123.

By species: Dog (1,761 reports), Cat (320 reports), Horse (2 reports). By breed: Domestic Shorthair (200), Retriever - Labrador (179), Crossbred Canine/dog (108).

Most co-reported drugs: Afoxolaner (224 reports), Milbemycin Oxime + Spinosad (212 reports), Ivermectin + Pyrantel As Pamoate Salt (144 reports), Bedinvetmab (133 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.