Reaction profile

The FDA adverse-event record for crying

1,675 FDA adverse-event reports reference crying (VeDDRA 130). See the species, breeds, and drugs most associated with it below.

1,675
reports citing this reaction
12.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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1,675
Total Reports
211
Deaths
12.6%
Death Rate

Species Most Affected

Dog 1,402
Cat 267
Sheep 1
Goat 1
Ferret 1
Cattle 1
Horse 1
Parrot 1

Breeds Most Affected

Domestic Shorthair 134
Retriever - Labrador 114
Crossbred Canine/dog 100
Chihuahua 95
Shih Tzu 76
Terrier - Yorkshire 57
Dog (unknown) 52
Retriever - Golden 50
Shepherd Dog - German 40
Maltese 38

Associated Drugs

Milbemycin Oxime + Spinosad 203
Afoxolaner 128
Bedinvetmab 89
Spinosad 82
Carprofen 80
Nitenpyram 77
Ivermectin + Pyrantel As Pamoate Salt 75
Pyrantel Pamoate;Sarolaner 73
Fluralaner Chew Tablets 68
Gabapentin 67
Maropitant Citrate 56
Moxidectin 51
Selamectin 47
Oclacitinib Maleate 45
Lotilaner 44
Buprenorphine 41
Prednisone 38
Milbemycin Oxime + Praziquantel 38
Fluralaner 13.64% 12-Week Chew 35
Melarsomine Dihydrochloride 31

Crying Reaction Insights

1,675 reports name Crying; 211 recorded a death outcome (12.6% of reported events, not a population-level mortality rate). VeDDRA code: 130.

By species: Dog (1,402 reports), Cat (267 reports), Sheep (1 reports). By breed: Domestic Shorthair (134), Retriever - Labrador (114), Crossbred Canine/dog (100).

Most co-reported drugs: Milbemycin Oxime + Spinosad (203 reports), Afoxolaner (128 reports), Bedinvetmab (89 reports), Spinosad (82 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.