Reaction profile

The FDA adverse-event record for ketonuria

589 FDA adverse-event reports reference ketonuria (VeDDRA 2910). See the species, breeds, and drugs most associated with it below.

589
reports citing this reaction
20.4%
death-coded share
Cat
most-affected species
Velagliflozin Proline Monohydrate
most-associated drug
Verify with FDA CVM →
589
Total Reports
120
Deaths
20.4%
Death Rate

Species Most Affected

Cat 544
Dog 45

Breeds Most Affected

Domestic Shorthair 390
Domestic Longhair 46
Domestic Mediumhair 38
Cat (unknown) 29
Maine Coon 9
Chihuahua 6
Retriever - Labrador 6
Ragdoll 6
Siamese 5
Crossbred Canine/dog 3

Associated Drugs

Velagliflozin Proline Monohydrate 420
Bexagliflozin 100
Maropitant Citrate 17
Bedinvetmab 15
Insulin 14
Senvelgo Velagliflozin Oral Solution 14
Fluid Therapy 13
Trilostane 10
Gabapentin 10
Cefovecin Sodium 9
Prescription Diet 8
Dextrose 8
Sc Fluids 8
Prednisone 6
Buprenorphine 6
Cefovecin 6
Enrofloxacin 5
Fluid Therapy (Unknown) 5
Metronidazole 5
Amoxicillin + Clavulanic Acid 5

Ketonuria Reaction Insights

589 reports name Ketonuria; 120 recorded a death outcome (20.4% of reported events, not a population-level mortality rate). VeDDRA code: 2910.

By species: Cat (544 reports), Dog (45 reports). By breed: Domestic Shorthair (390), Domestic Longhair (46), Domestic Mediumhair (38).

Most co-reported drugs: Velagliflozin Proline Monohydrate (420 reports), Bexagliflozin (100 reports), Maropitant Citrate (17 reports), Bedinvetmab (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.