Reaction profile

The FDA adverse-event record for localised itching

684 FDA adverse-event reports reference localised itching (VeDDRA 1582). See the species, breeds, and drugs most associated with it below.

684
reports citing this reaction
0.9%
death-coded share
Dog
most-affected species
Frunevetmab
most-associated drug
Verify with FDA CVM →
684
Total Reports
6
Deaths
0.9%
Death Rate

Species Most Affected

Dog 516
Cat 133
Human 22
Horse 6
Cattle 4
Donkey 3

Breeds Most Affected

Domestic Shorthair 91
Retriever - Labrador 54
Crossbred Canine/dog 31
Unknown 24
Shih Tzu 22
Shepherd Dog - German 20
Retriever - Golden 20
Domestic Longhair 18
Terrier - Yorkshire 17
Chihuahua 17

Associated Drugs

Frunevetmab 70
Milbemycin Oxime + Spinosad 64
Moxidectin 54
Fluralaner Chew Tablets 43
Afoxolaner 35
Spinosad 32
Oclacitinib Maleate 27
Nitenpyram 23
Selamectin 22
Fluralaner 13.64% 12-Week Chew 20
Lufenuron + Milbemycin Oxime 18
Carprofen 18
Imidacloprid + Moxidectin 18
Ivermectin + Pyrantel As Pamoate Salt 18
Cefovecin 18
Milbemycin Oxime + Praziquantel 15
Fluralaner Spot-On Solution 14
Gabapentin 14
Prednisone 12
Cyclosporine A 12

Localised itching Reaction Insights

684 reports name Localised itching; 6 recorded a death outcome (0.9% of reported events, not a population-level mortality rate). VeDDRA code: 1582.

By species: Dog (516 reports), Cat (133 reports), Human (22 reports). By breed: Domestic Shorthair (91), Retriever - Labrador (54), Crossbred Canine/dog (31).

Most co-reported drugs: Frunevetmab (70 reports), Milbemycin Oxime + Spinosad (64 reports), Moxidectin (54 reports), Fluralaner Chew Tablets (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.