Reaction profile

The FDA adverse-event record for vomiting

174,348 FDA reports name vomiting, a high-volume reaction in the CVM extract (VeDDRA 334). Plate stamps and neighbourhood peers follow.

#1 of 2,481
by report volume (all reactions)
174,348
reports citing this reaction
4.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Vomiting has 174,348 reports now versus 172,793 in that prior snapshot: 1,555 more (0.9%).

Report change
+1,555
Death-coded reports
+77
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Vomiting changes

FDA AER · VeDDRA plate

Code 334 VOL-MEGA

VOL-MEGA · DEATH-LOW · TOP-DECILE · CLEAR-GAP · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MEGA 174,348 reports
  • DEATH-LOW 4.3%
  • TOP-DECILE #1/2481
  • CLEAR-GAP Lethargy (see also Ce…
  • SPECIES-DOG Dog · 159,370
  • DRUG-LEAD Milbemycin Oxime… · 33,692
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Lethargy (see also Central nervous system depression in 'Neurological') (±81,546 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Vomiting

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · this reaction174348Lethargy (see also Ce… · near92802Emesis · near69317Diarrhoea · near64292Lack of efficacy (ect… · near59231Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Vomiting

Vomiting: low death-coded share in the FDA AER plate

Signature read: 174,348 reports place Vomiting in the upper third of FDA AER volume (#1 of 2,481). Report volume is upper-third scale: 174,348 named reports in the openFDA extract. Death-coded share is lower-third: 7,526 of 174,348 reports (4.3% of named reports). Nearest volume peer: Lethargy (see also Central nervous system depression in 'Neurological') (±81,546 reports). Lead species Dog (159,370). Lead co-reported drug Milbemycin Oxime + Spinosad (33,692).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 159,370
Cat 14,615
Human 205
Unknown 76
Pig 17
Other 16
Other Canids 11
Ferret 10
Goat 6
Cattle 4

Breeds Most Affected

Retriever - Labrador 15,717
Crossbred Canine/dog 15,399
Dog (unknown) 8,471
Domestic Shorthair 8,026
Chihuahua 6,846
Retriever - Golden 6,763
Terrier - Yorkshire 6,371
Shih Tzu 6,022
Shepherd Dog - German 4,601
Boxer (German Boxer) 4,057

Associated Drugs

Milbemycin Oxime + Spinosad 33,692
Spinosad 17,214
Afoxolaner 13,114
Fluralaner Chew Tablets 11,977
Ivermectin + Pyrantel As Pamoate Salt 9,884
Pyrantel Pamoate;Sarolaner 8,977
Moxidectin 8,333
Milbemycin Oxime + Praziquantel 6,565
Fluralaner 13.64% 12-Week Chew 6,449
Carprofen 5,550
Maropitant Citrate 3,962
Sarolaner 3,858
Oclacitinib Maleate 3,331
Lotilaner 2,964
Trilostane 2,611
Selamectin 2,532
Spinosad, Milbemycin 2,279
Cyclosporine 2,232
Febantel + Praziquantel + Pyrantel Pamoate 1,920
Meloxicam 1,733

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Vomiting, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (4.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Vomiting (#1 of 2,481 by report volume); death-coded 4.3%. PlainBreed reaction plate · report volume stamp 174,348 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →