Reaction profile

The FDA adverse-event record for vomiting

170,697 FDA adverse-event reports reference vomiting (VeDDRA 334). See the species, breeds, and drugs most associated with it below.

170,697
reports citing this reaction
4.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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170,697
Total Reports
7,313
Deaths
4.3%
Death Rate

Species Most Affected

Dog 156,330
Cat 14,016
Human 201
Unknown 75
Pig 15
Other 13
Other Canids 11
Ferret 10
Goat 4
Cattle 4

Breeds Most Affected

Retriever - Labrador 15,438
Crossbred Canine/dog 15,157
Dog (unknown) 8,278
Domestic Shorthair 7,669
Chihuahua 6,728
Retriever - Golden 6,544
Terrier - Yorkshire 6,294
Shih Tzu 5,923
Shepherd Dog - German 4,509
Boxer (German Boxer) 4,006

Associated Drugs

Milbemycin Oxime + Spinosad 33,623
Spinosad 17,208
Afoxolaner 12,941
Fluralaner Chew Tablets 11,977
Ivermectin + Pyrantel As Pamoate Salt 9,752
Pyrantel Pamoate;Sarolaner 8,460
Moxidectin 8,121
Milbemycin Oxime + Praziquantel 6,439
Fluralaner 13.64% 12-Week Chew 6,194
Carprofen 5,415
Sarolaner 3,807
Maropitant Citrate 3,768
Oclacitinib Maleate 3,169
Lotilaner 2,850
Trilostane 2,547
Selamectin 2,511
Spinosad, Milbemycin 2,279
Cyclosporine 2,185
Febantel + Praziquantel + Pyrantel Pamoate 1,880
Meloxicam 1,698

Vomiting Reaction Insights

170,697 reports name Vomiting; 7,313 recorded a death outcome (4.3% of reported events, not a population-level mortality rate). VeDDRA code: 334.

By species: Dog (156,330 reports), Cat (14,016 reports), Human (201 reports). By breed: Retriever - Labrador (15,438), Crossbred Canine/dog (15,157), Dog (unknown) (8,278).

Most co-reported drugs: Milbemycin Oxime + Spinosad (33,623 reports), Spinosad (17,208 reports), Afoxolaner (12,941 reports), Fluralaner Chew Tablets (11,977 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.