Reaction profile

The FDA adverse-event record for local erythema

148 FDA adverse-event reports reference local erythema (VeDDRA 3129). See the species, breeds, and drugs most associated with it below.

148
reports citing this reaction
4.1%
death-coded share
Dog
most-affected species
Frunevetmab
most-associated drug
Verify with FDA CVM →
148
Total Reports
6
Deaths
4.1%
Death Rate

Species Most Affected

Dog 113
Cat 32
Human 3

Breeds Most Affected

Domestic Shorthair 23
Bulldog - French 9
Dachshund (unspecified) 8
Terrier - Bull - American Pit 8
Crossbred Canine/dog 7
Retriever - Labrador 7
Terrier - Yorkshire 5
Shepherd Dog - German 5
Chihuahua 4
Pit Bull 4

Associated Drugs

Frunevetmab 23
Diphenhydramine 20
Gabapentin 20
Oclacitinib Maleate 20
Bedinvetmab 15
Maropitant Citrate 15
Carprofen 14
Prednisone 14
Tigilanol Tiglate 13
Moxidectin 13
Famotidine 11
Anti-Il31 Mab Mcs Lot #1283563 11
Cefovecin 10
Pyrantel Pamoate;Sarolaner 10
Unspecified 10
Buprenorphine 9
Cyclosporine 7
Dexamethasone 7
Butorphanol 6
Methadone 6

Local erythema Reaction Insights

148 reports name Local erythema; 6 recorded a death outcome (4.1% of reported events, not a population-level mortality rate). VeDDRA code: 3129.

By species: Dog (113 reports), Cat (32 reports), Human (3 reports). By breed: Domestic Shorthair (23), Bulldog - French (9), Dachshund (unspecified) (8).

Most co-reported drugs: Frunevetmab (23 reports), Diphenhydramine (20 reports), Gabapentin (20 reports), Oclacitinib Maleate (20 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.