Reaction profile

The FDA adverse-event record for emesis

69,317 FDA reports name emesis, a high-volume reaction in the CVM extract (VeDDRA 335). Plate stamps and neighbourhood peers follow.

#3 of 2,481
by report volume (all reactions)
69,317
reports citing this reaction
1.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Emesis has 69,317 reports now versus 69,268 in that prior snapshot: 49 more (0.1%).

Report change
+49
Death-coded reports
+2
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Emesis changes

FDA AER · VeDDRA plate

Code 335 VOL-MEGA

VOL-MEGA · DEATH-LOW · TOP-DECILE · NEAR-PEER · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MEGA 69,317 reports
  • DEATH-LOW 1.4%
  • TOP-DECILE #3/2481
  • NEAR-PEER Diarrhoea
  • SPECIES-DOG Dog · 63,502
  • DRUG-LEAD Milbemycin Oxime… · 43,148
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Diarrhoea (±5,025 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Emesis

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Emesis · this reaction69317Diarrhoea · near64292Lack of efficacy (ect… · near59231Lack of efficacy - NOS · near54525Lack of efficacy (end… · near52770Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Emesis

Emesis: low death-coded share in the FDA AER plate

Signature read: 69,317 reports place Emesis in the upper third of FDA AER volume (#3 of 2,481). Report volume is upper-third scale: 69,317 named reports in the openFDA extract. Death-coded share is lower-third: 953 of 69,317 reports (1.4% of named reports). Nearest volume peer: Diarrhoea (±5,025 reports). Lead species Dog (63,502). Lead co-reported drug Milbemycin Oxime + Spinosad (43,148).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 63,502
Cat 5,676
Unknown 76
Human 41
Other Canids 4
Cattle 4
Pig 3
Goat 3
Ferret 2
Wolf 2

Breeds Most Affected

Retriever - Labrador 6,720
Domestic Shorthair 3,454
Crossbred Canine/dog 2,966
Shih Tzu 2,888
Chihuahua 2,883
Terrier - Yorkshire 2,852
Boxer (German Boxer) 2,239
Retriever - Golden 2,017
Shepherd Dog - German 1,929
Pit Bull 1,693

Associated Drugs

Milbemycin Oxime + Spinosad 43,148
Spinosad 19,055
Ivermectin 1,470
Moxidectin 1,070
Carprofen 955
Ivermectin + Pyrantel As Pamoate Salt 951
Cyclosporine A 920
Vaccines (Unknown) 865
Febantel + Praziquantel + Pyrantel Pamoate 606
Lufenuron + Milbemycin Oxime 597
Maropitant Citrate 579
Ivermectin + Pyrantel Pamoate 577
Prednisone 569
Afoxolaner 561
Milbemycin Oxime 487
Rabies Vaccine 459
Cephalexin 373
Pyrantel Pamoate;Sarolaner 349
Diphenhydramine 343
Tramadol 327

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Emesis, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (1.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Emesis (#3 of 2,481 by report volume); death-coded 1.4%. PlainBreed reaction plate · report volume stamp 69,317 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →