Reaction profile

The FDA adverse-event record for vascular disorder nos (see also endocarditis)

177 FDA adverse-event reports reference vascular disorder nos (see also endocarditis) (VeDDRA 246). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1099 of 2,481
by report volume (all reactions)
177
reports citing this reaction
39.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Vascular disorder NOS (see also endocarditis) has 177 reports now versus 174 in that prior snapshot: 3 more (1.7%).

Report change
+3
Death-coded reports
+1
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Vascular disorder NOS (see also endocarditis) changes

FDA AER · VeDDRA plate

Code 246 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 177 reports
  • DEATH-HOT 39.5%
  • MID-PACK #1099/2481
  • PHOTO-FINISH Choke
  • SPECIES-DOG Dog · 143
  • DRUG-LEAD Moxidectin · 23
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Choke (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Vascular disorder NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Choke · near177Decreased respiratory… · near177Ptyalism · near177Vascular disorder NOS… · thi…177Agonal breathing · near176Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Vascular disorder NOS (see also endocarditis)

Vascular disorder NOS (see also endocarditis): high death-coded share in the FDA AER plate

Signature read: Vascular disorder NOS (see also endocarditis)'s 39.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 70 of 177 reports (39.5% of named reports). Nearest volume peer: Choke (±0 reports). Lead species Dog (143). Lead co-reported drug Moxidectin (23).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 143
Cat 25
Cattle 3
Horse 3
Pig 2
Chicken 1

Breeds Most Affected

Retriever - Labrador 24
Domestic Shorthair 15
Crossbred Canine/dog 13
Shepherd Dog - German 10
Terrier - Yorkshire 5
Terrier - Bull - American Pit 5
Shih Tzu 5
Boxer (German Boxer) 4
Dachshund (unspecified) 4
Chihuahua 3

Associated Drugs

Moxidectin 23
Milbemycin Oxime + Spinosad 18
Carprofen 14
Prednisone 12
Ivermectin + Pyrantel As Pamoate Salt 12
Cefovecin 11
Spinosad 10
Diphenhydramine Hcl 10
Maropitant Citrate 10
Buprenorphine 10
Dexamethasone 9
Dexmedetomidine Hydrochloride 8
Milbemycin Oxime, Lufenuron 8
Lufenuron + Milbemycin Oxime 7
Rabies Virus, Kv 7
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 6
Enrofloxacin 6
Ivermectin 5
Melarsomine Dihydrochloride Injection 5
Atipamezole Hydrochloride 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Vascular disorder NOS (see also endocarditis), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (177 here).

Similar death-coded share

Nearest other reactions by death-coded share (39.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Vascular disorder NOS (see also endocarditis) (#1099 of 2,481 by report volume); death-coded 39.5%. PlainBreed reaction plate · death-coded share stamp 39.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →