Reaction profile

The FDA adverse-event record for vascular disorder nos (see also endocarditis)

169 FDA adverse-event reports reference vascular disorder nos (see also endocarditis) (VeDDRA 246). See the species, breeds, and drugs most associated with it below.

169
reports citing this reaction
39.1%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
169
Total Reports
66
Deaths
39.1%
Death Rate

Species Most Affected

Dog 141
Cat 23
Pig 2
Chicken 1
Cattle 1
Horse 1

Breeds Most Affected

Retriever - Labrador 24
Domestic Shorthair 14
Crossbred Canine/dog 13
Shepherd Dog - German 10
Terrier - Yorkshire 5
Shih Tzu 5
Terrier - Bull - American Pit 4
Dachshund (unspecified) 4
Chihuahua 3
Shepherd Dog - Australian 3

Associated Drugs

Moxidectin 22
Milbemycin Oxime + Spinosad 18
Carprofen 14
Prednisone 12
Ivermectin + Pyrantel As Pamoate Salt 12
Spinosad 10
Maropitant Citrate 10
Buprenorphine 10
Diphenhydramine Hcl 10
Cefovecin 10
Dexamethasone 9
Dexmedetomidine Hydrochloride 8
Milbemycin Oxime, Lufenuron 8
Lufenuron + Milbemycin Oxime 7
Rabies Virus, Kv 7
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 6
Enrofloxacin 6
Ivermectin 5
Melarsomine Dihydrochloride Injection 5
Atipamezole Hydrochloride 5

Vascular disorder NOS (see also endocarditis) Reaction Insights

169 reports name Vascular disorder NOS (see also endocarditis); 66 recorded a death outcome (39.1% of reported events, not a population-level mortality rate). VeDDRA code: 246.

By species: Dog (141 reports), Cat (23 reports), Pig (2 reports). By breed: Retriever - Labrador (24), Domestic Shorthair (14), Crossbred Canine/dog (13).

Most co-reported drugs: Moxidectin (22 reports), Milbemycin Oxime + Spinosad (18 reports), Carprofen (14 reports), Prednisone (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.