Reaction profile

The FDA adverse-event record for decreased respiratory rate

177 FDA adverse-event reports reference decreased respiratory rate (VeDDRA 834). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1097 of 2,481
by report volume (all reactions)
177
reports citing this reaction
30.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Decreased respiratory rate has 177 reports now versus 175 in that prior snapshot: 2 more (1.1%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Decreased respiratory rate changes

FDA AER · VeDDRA plate

Code 834 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 177 reports
  • DEATH-HOT 30.5%
  • MID-PACK #1097/2481
  • PHOTO-FINISH Choke
  • SPECIES-DOG Dog · 125
  • DRUG-LEAD Isoflurane · 32
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Choke (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Decreased respiratory rate

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Choke · near177Decreased respiratory… · thi…177Ptyalism · near177Vascular disorder NOS… · near177Agonal breathing · near176Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Decreased respiratory rate

Decreased respiratory rate: high death-coded share in the FDA AER plate

Signature read: Decreased respiratory rate's 30.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 54 of 177 reports (30.5% of named reports). Nearest volume peer: Choke (±0 reports). Lead species Dog (125). Lead co-reported drug Isoflurane (32).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 125
Cat 44
Mouse 2
Horse 2
Pig 1
Rabbit 1
Sheep 1
Monkey 1

Breeds Most Affected

Domestic Shorthair 25
Dog (unknown) 11
Cat (unknown) 9
Crossbred Canine/dog 8
Chihuahua 7
Boxer (German Boxer) 7
Shepherd Dog - German 7
Retriever - Labrador 6
Spitz - German Pomeranian 5
Terrier - Yorkshire 4

Associated Drugs

Isoflurane 32
Dexmedetomidine Hydrochloride 26
Buprenorphine 21
Milbemycin Oxime + Spinosad 18
Maropitant Citrate 16
Butorphanol Tartrate 12
Ketamine 12
Propofol 11
Atipamezole Hydrochloride 10
Acepromazine 10
Moxidectin 9
Methimazole 9
Epinephrine 8
Dexmedetomidine 8
Gabapentin 8
Spinosad 7
Cefovecin 7
Bedinvetmab 7
Butorphanol 6
Diazepam 6

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Decreased respiratory rate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (177 here).

Similar death-coded share

Nearest other reactions by death-coded share (30.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Decreased respiratory rate (#1097 of 2,481 by report volume); death-coded 30.5%. PlainBreed reaction plate · death-coded share stamp 30.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →