Reaction profile

The FDA adverse-event record for vaginal haemorrhage

132 FDA adverse-event reports reference vaginal haemorrhage (VeDDRA 817). See the species, breeds, and drugs most associated with it below.

132
reports citing this reaction
15.2%
death-coded share
Dog
most-affected species
Estriol Tablets
most-associated drug
Verify with FDA CVM →
132
Total Reports
20
Deaths
15.2%
Death Rate

Species Most Affected

Dog 112
Human 8
Cat 5
Other 2
Cattle 2
Horse 1
Goat 1
Hamster 1

Breeds Most Affected

Crossbred Canine/dog 20
Unknown 10
Retriever - Labrador 10
Doberman Pinscher 7
Beagle 6
Chihuahua 5
Pug 4
Poodle - Toy 3
Spaniel - King Charles Cavalier 3
Domestic (unspecified) 2

Associated Drugs

Estriol Tablets 56
Estriol 10
Carprofen 8
Milbemycin Oxime + Spinosad 5
Fluralaner Chew Tablets 5
Bedinvetmab 5
Oclacitinib Maleate 4
Gabapentin 4
Progesterone 3
Maropitant Citrate 3
Famotidine 3
Milbemycin Oxime + Praziquantel 3
Selamectin 2
Melarsomine Dihydrochloride 2
Altrenogest 2
Dinoprost Tromethamine 2
Spinosad 2
Firocoxib 2
Cefovecin 2
Device: Suture 2

Vaginal haemorrhage Reaction Insights

132 reports name Vaginal haemorrhage; 20 recorded a death outcome (15.2% of reported events, not a population-level mortality rate). VeDDRA code: 817.

By species: Dog (112 reports), Human (8 reports), Cat (5 reports). By breed: Crossbred Canine/dog (20), Unknown (10), Retriever - Labrador (10).

Most co-reported drugs: Estriol Tablets (56 reports), Estriol (10 reports), Carprofen (8 reports), Milbemycin Oxime + Spinosad (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.