Reaction profile

The FDA adverse-event record for preputial discharge

62 FDA adverse-event reports reference preputial discharge (VeDDRA 799). See the species, breeds, and drugs most associated with it below.

62
reports citing this reaction
11.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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62
Total Reports
7
Deaths
11.3%
Death Rate

Species Most Affected

Dog 60
Cat 1
Horse 1

Breeds Most Affected

Boxer (German Boxer) 6
Retriever - Labrador 6
Retriever - Golden 5
Pit Bull 4
Bulldog 3
Shepherd Dog - German 3
Spaniel (unspecified) 2
Shih Tzu 2
Spitz - German Pomeranian 2
Spaniel - King Charles Cavalier 2

Associated Drugs

Milbemycin Oxime + Spinosad 12
Oclacitinib Maleate 9
Carprofen 7
Bedinvetmab 7
Trilostane 6
Ivermectin + Pyrantel As Pamoate Salt 6
Fluralaner Chew Tablets 5
Afoxolaner 4
Spinosad 3
Pimobendan 3
Enrofloxacin 3
Prednisone 3
Anti-Il31 Mab Mcs Lot #1283563 3
Milbemycin Oxime + Praziquantel 3
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 2
Phenobarbital 2
Lotilaner 2
Polysulfated Glycosaminoglycan 2
Miconazole Nitrate + Chloroxylenol 1
Insulin 1

Preputial discharge Reaction Insights

62 reports name Preputial discharge; 7 recorded a death outcome (11.3% of reported events, not a population-level mortality rate). VeDDRA code: 799.

By species: Dog (60 reports), Cat (1 reports), Horse (1 reports). By breed: Boxer (German Boxer) (6), Retriever - Labrador (6), Retriever - Golden (5).

Most co-reported drugs: Milbemycin Oxime + Spinosad (12 reports), Oclacitinib Maleate (9 reports), Carprofen (7 reports), Bedinvetmab (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.