Reaction profile

The FDA adverse-event record for preputial discharge

64 FDA adverse-event reports reference preputial discharge (VeDDRA 799). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1621 of 2,481
by report volume (all reactions)
64
reports citing this reaction
10.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Preputial discharge has 64 reports now versus 63 in that prior snapshot: 1 more (1.6%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Preputial discharge changes

FDA AER · VeDDRA plate

Code 799 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 64 reports
  • DEATH-ELEV 10.9%
  • MID-PACK #1621/2481
  • PHOTO-FINISH Lacrimation
  • SPECIES-DOG Dog · 62
  • DRUG-LEAD Milbemycin Oxime… · 12
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Lacrimation (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Preputial discharge

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Acne · near65Lacrimation · near64Preputial discharge · this r…64Snoring · near64Spherocytosis · near64Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Preputial discharge

What the FDA AER plate says about Preputial discharge

Signature read: 7 death-coded reports is a thin tail count for Preputial discharge in the CVM extract. Report volume sits in the middle third of the reaction corpus. 7 of 64 reports were death-coded (10.9% of named reports, not a population mortality rate). Nearest volume peer: Lacrimation (±0 reports). Lead species Dog (62). Lead co-reported drug Milbemycin Oxime + Spinosad (12).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 62
Cat 1
Horse 1

Breeds Most Affected

Boxer (German Boxer) 6
Retriever - Labrador 6
Retriever - Golden 6
Pit Bull 4
Bulldog 3
Shepherd Dog - German 3
Spaniel (unspecified) 2
Spitz - German Pomeranian 2
Shih Tzu 2
Spaniel - King Charles Cavalier 2

Associated Drugs

Milbemycin Oxime + Spinosad 12
Oclacitinib Maleate 9
Bedinvetmab 9
Carprofen 8
Trilostane 6
Ivermectin + Pyrantel As Pamoate Salt 6
Fluralaner Chew Tablets 5
Afoxolaner 4
Spinosad 3
Pimobendan 3
Enrofloxacin 3
Prednisone 3
Anti-Il31 Mab Mcs Lot #1283563 3
Milbemycin Oxime + Praziquantel 3
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 2
Phenobarbital 2
Lotilaner 2
Polysulfated Glycosaminoglycan 2
Miconazole Nitrate + Chloroxylenol 1
Insulin 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Preputial discharge, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (64 here).

Similar death-coded share

Nearest other reactions by death-coded share (10.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Preputial discharge (#1621 of 2,481 by report volume); death-coded 10.9%. PlainBreed reaction plate · death-coded report count stamp 7 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →