Reaction profile

The FDA adverse-event record for urination

522 FDA adverse-event reports reference urination (VeDDRA 1161). See the species, breeds, and drugs most associated with it below.

522
reports citing this reaction
16.9%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
522
Total Reports
88
Deaths
16.9%
Death Rate

Species Most Affected

Dog 436
Cat 85
Cattle 1

Breeds Most Affected

Retriever - Labrador 37
Crossbred Canine/dog 35
Domestic Shorthair 33
Boxer (German Boxer) 27
Shih Tzu 22
Retriever - Golden 22
Domestic (unspecified) 21
Shepherd Dog - German 15
Chihuahua 14
Dachshund (unspecified) 13

Associated Drugs

Afoxolaner 60
Moxidectin 41
Milbemycin Oxime + Spinosad 33
Fluralaner Chew Tablets 26
Ivermectin + Pyrantel As Pamoate Salt 24
Spinosad 21
Pyrantel Pamoate;Sarolaner 20
Milbemycin Oxime + Praziquantel 18
Carprofen 17
Melarsomine Dihydrochloride Injection 17
Maropitant Citrate 17
Lotilaner 17
Melarsomine Dihydrochloride 16
Nitenpyram 15
Cefovecin Sodium 14
Sarolaner 13
Rabies Virus, 13
Buprenorphine 12
Selamectin 10
Oclacitinib Maleate 10

Urination Reaction Insights

522 reports name Urination; 88 recorded a death outcome (16.9% of reported events, not a population-level mortality rate). VeDDRA code: 1161.

By species: Dog (436 reports), Cat (85 reports), Cattle (1 reports). By breed: Retriever - Labrador (37), Crossbred Canine/dog (35), Domestic Shorthair (33).

Most co-reported drugs: Afoxolaner (60 reports), Moxidectin (41 reports), Milbemycin Oxime + Spinosad (33 reports), Fluralaner Chew Tablets (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.