Reaction profile

The FDA adverse-event record for prolonged capillary refill time

511 FDA adverse-event reports reference prolonged capillary refill time (VeDDRA 1937). See the species, breeds, and drugs most associated with it below.

511
reports citing this reaction
29.5%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
511
Total Reports
151
Deaths
29.5%
Death Rate

Species Most Affected

Dog 457
Cat 37
Horse 16
Pig 1

Breeds Most Affected

Retriever - Labrador 46
Crossbred Canine/dog 31
Domestic Shorthair 26
Boxer (German Boxer) 21
Retriever - Golden 21
Dachshund (unspecified) 17
Chihuahua 15
Shepherd Dog - German 12
Terrier - Yorkshire 11
Beagle 10

Associated Drugs

Moxidectin 95
Milbemycin Oxime + Spinosad 55
Maropitant Citrate 44
Carprofen 43
Gabapentin 21
Melarsomine Dihydrochloride 20
Spinosad 20
Deracoxib 19
Enrofloxacin 19
Rabies Virus, Kv 18
Meloxicam 16
Diphenhydramine Hcl 16
Metronidazole 16
Dexamethasone 16
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 16
Bedinvetmab 16
Buprenorphine 15
Famotidine 15
Firocoxib 14
Tramadol 14

Prolonged capillary refill time Reaction Insights

511 reports name Prolonged capillary refill time; 151 recorded a death outcome (29.5% of reported events, not a population-level mortality rate). VeDDRA code: 1937.

By species: Dog (457 reports), Cat (37 reports), Horse (16 reports). By breed: Retriever - Labrador (46), Crossbred Canine/dog (31), Domestic Shorthair (26).

Most co-reported drugs: Moxidectin (95 reports), Milbemycin Oxime + Spinosad (55 reports), Maropitant Citrate (44 reports), Carprofen (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.