Reaction profile

The FDA adverse-event record for involuntary defecation

673 FDA reports name involuntary defecation, a high-volume reaction in the CVM extract (VeDDRA 270). Plate stamps and neighbourhood peers follow.

#528 of 2,481
by report volume (all reactions)
673
reports citing this reaction
17.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Involuntary defecation has 673 reports now versus 659 in that prior snapshot: 14 more (2.1%).

Report change
+14
Death-coded reports
+1
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Involuntary defecation changes

FDA AER · VeDDRA plate

Code 270 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 673 reports
  • DEATH-ELEV 17.4%
  • UPPER-Q #528/2481
  • PHOTO-FINISH Respiratory arrest
  • SPECIES-DOG Dog · 605
  • DRUG-LEAD Moxidectin · 134
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Respiratory arrest (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Involuntary defecation

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Other ear disorder NOS · near675Involuntary defecation · thi…673Respiratory arrest · near673Unrelated death · near673Lack of efficacy (pro… · near670Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Involuntary defecation

What the FDA AER plate says about Involuntary defecation

Signature read: 117 death-coded reports is a heavy tail count for Involuntary defecation in the CVM extract. Report volume is upper-third scale: 673 named reports in the openFDA extract. 117 of 673 reports were death-coded (17.4% of named reports, not a population mortality rate). Nearest volume peer: Respiratory arrest (±0 reports). Lead species Dog (605). Lead co-reported drug Moxidectin (134).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 605
Cat 62
Horse 2
Cattle 2
Other Canids 1
Human 1

Breeds Most Affected

Retriever - Labrador 64
Domestic Shorthair 39
Chihuahua 33
Crossbred Canine/dog 28
Shih Tzu 25
Terrier - Yorkshire 25
Terrier - Bull - American Pit 24
Retriever - Golden 22
Dog (unknown) 20
Beagle 18

Associated Drugs

Moxidectin 134
Bedinvetmab 47
Maropitant Citrate 46
Melarsomine Dihydrochloride 46
Afoxolaner 42
Pyrantel Pamoate;Sarolaner 40
Milbemycin Oxime + Spinosad 29
Prednisone 29
Gabapentin 29
Carprofen 28
Fluralaner Chew Tablets 27
Cefovecin 24
Fluralaner 13.64% 12-Week Chew 21
Melarsomine Dihydrochloride Injection 20
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 20
Rabies Virus, Kv 20
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 20
Dexamethasone 19
Diphenhydramine Hcl 19
Sarolaner 18

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Involuntary defecation, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (673 here).

Similar death-coded share

Nearest other reactions by death-coded share (17.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Involuntary defecation (#528 of 2,481 by report volume); death-coded 17.4%. PlainBreed reaction plate · death-coded report count stamp 117 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →