Reaction profile
The FDA adverse-event record for unresponsive to stimuli
1,604 FDA adverse-event reports reference unresponsive to stimuli (VeDDRA 2247). See the species, breeds, and drugs most associated with it below.
- 1,604
- reports citing this reaction
- 35.0%
- death-coded share
- Dog
- most-affected species
- Milbemycin Oxime + Spinosad
- most-associated drug
Species Most Affected
Breeds Most Affected
Associated Drugs
Unresponsive to stimuli Reaction Insights
1,604 reports name Unresponsive to stimuli; 562 recorded a death outcome (35.0% of reported events, not a population-level mortality rate). VeDDRA code: 2247.
By species: Dog (1,249 reports), Cat (328 reports), Horse (11 reports). By breed: Domestic Shorthair (214), Retriever - Labrador (114), Crossbred Canine/dog (82).
Most co-reported drugs: Milbemycin Oxime + Spinosad (161 reports), Maropitant Citrate (142 reports), Afoxolaner (142 reports), Moxidectin (131 reports).
Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.