Reaction profile

The FDA adverse-event record for loss of hearing

1,707 FDA reports name loss of hearing, a high-volume reaction in the CVM extract (VeDDRA 1591). Plate stamps and neighbourhood peers follow.

#261 of 2,481
by report volume (all reactions)
1,707
reports citing this reaction
3.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Loss of hearing has 1,707 reports now versus 1,646 in that prior snapshot: 61 more (3.7%).

Report change
+61
Death-coded reports
+1
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Loss of hearing changes

FDA AER · VeDDRA plate

Code 1591 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,707 reports
  • DEATH-LOW 3.2%
  • UPPER-Q #261/2481
  • PHOTO-FINISH Localised hair loss
  • SPECIES-DOG Dog · 1,646
  • DRUG-LEAD Gentamicin Sulfat… · 252
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Localised hair loss (±5 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Loss of hearing

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Localised hair loss · near1712Loss of hearing · this react…1707Unresponsive to stimu… · near1696Application site lesi… · near1693Renal disorder NOS · near1684Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Loss of hearing

Loss of hearing: low death-coded share in the FDA AER plate

Signature read: 1,707 reports place Loss of hearing in the upper third of FDA AER volume (#261 of 2,481). Report volume is upper-third scale: 1,707 named reports in the openFDA extract. Death-coded share is lower-third: 54 of 1,707 reports (3.2% of named reports). Nearest volume peer: Localised hair loss (±5 reports). Lead species Dog (1,646). Lead co-reported drug Gentamicin Sulfate + Hydrocortisone Aceponate + Miconazole Nitrate (252).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Gentamicin Sulfate + Hydrocortisone Aceponate + Miconazole Nitrate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,646
Cat 58
Rat 1
Human 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 142
Crossbred Canine/dog 89
Terrier - Yorkshire 87
Chihuahua 71
Unknown 69
Pit Bull 69
Dog (unknown) 64
Maltese 62
Shepherd Dog - German 55
Pug 55

Associated Drugs

Gentamicin Sulfate + Hydrocortisone Aceponate + Miconazole Nitrate 252
Clotrimazole + Gentamicin + Mometasone 228
Miconazole + Polymyxin B + Prednisolone 205
Betamethasone + Florfenicol + Terbinafine 112
Genta/Momet/Clotrim Ear Oint 91
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 90
Bedinvetmab 82
Carprofen 65
Oclacitinib Maleate 61
Orbiflox/Momet/Posaco Eardrops 59
Gentamicin Sulfate, Usp; Mometasone Furoate Anhydrous, Usp; Clotrimazole, Usp 57
Neomycin Sulfate Equivalent To Neomycin Base + Nystatin + Thiostrepton + Triamcinolone Acetonide 51
Miconazole Nitrate + Polymyxin B Sulfate + Prednisolone Acetate 42
Florfenicol, Terbinafine, Betamethasone Acetate 41
Prednisone 39
Hydrocortisone Aceponate/Miconazole Nitrate/Gentamicin Sulfate 39
Gabapentin 37
Ear Cleaner (Unknown) 33
Salicylic Acid 31
Afoxolaner 25

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Loss of hearing, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,707 here).

Similar death-coded share

Nearest other reactions by death-coded share (3.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Loss of hearing (#261 of 2,481 by report volume); death-coded 3.2%. PlainBreed reaction plate · report volume stamp 1,707 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →