Reaction profile

The FDA adverse-event record for coughing blood

69 FDA adverse-event reports reference coughing blood (VeDDRA 1259). See the species, breeds, and drugs most associated with it below.

69
reports citing this reaction
36.2%
death-coded share
Dog
most-affected species
Melarsomine Dihydrochloride Injection
most-associated drug
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69
Total Reports
25
Deaths
36.2%
Death Rate

Species Most Affected

Dog 66
Cat 2
Turtle 1

Breeds Most Affected

Retriever - Labrador 7
Pit Bull 7
Crossbred Canine/dog 4
Shepherd Dog - Australian 3
Bulldog 3
Chihuahua 3
Terrier - Yorkshire 2
Deutsche Dogge, Great Dane 2
Dachshund (unspecified) 2
Dog (unknown) 2

Associated Drugs

Melarsomine Dihydrochloride Injection 15
Melarsomine Dihydrochloride 7
Ivermectin + Pyrantel As Pamoate Salt 6
Milbemycin Oxime + Spinosad 5
Carprofen 4
Maropitant Citrate 4
Bedinvetmab 4
Ketamine 3
Atipamezole Hydrochloride 3
Furosemide 3
Afoxolaner 3
Spinosad 3
Metronidazole 3
Meloxicam 3
Fluralaner Chew Tablets 3
Doxycycline 3
Lufenuron + Milbemycin Oxime + Praziquantel 3
Milbemycin Oxime + Praziquantel 3
Milbemycin Oxime 2
Prednisone 2

Coughing blood Reaction Insights

69 reports name Coughing blood; 25 recorded a death outcome (36.2% of reported events, not a population-level mortality rate). VeDDRA code: 1259.

By species: Dog (66 reports), Cat (2 reports), Turtle (1 reports). By breed: Retriever - Labrador (7), Pit Bull (7), Crossbred Canine/dog (4).

Most co-reported drugs: Melarsomine Dihydrochloride Injection (15 reports), Melarsomine Dihydrochloride (7 reports), Ivermectin + Pyrantel As Pamoate Salt (6 reports), Milbemycin Oxime + Spinosad (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.