Reaction profile

The FDA adverse-event record for sunken eyes

119 FDA adverse-event reports reference sunken eyes (VeDDRA 2273). See the species, breeds, and drugs most associated with it below.

119
reports citing this reaction
35.3%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
119
Total Reports
42
Deaths
35.3%
Death Rate

Species Most Affected

Dog 75
Cat 37
Cattle 6
Horse 1

Breeds Most Affected

Domestic Shorthair 12
Retriever - Labrador 10
Pit Bull 6
Domestic Longhair 6
Boxer (German Boxer) 4
Shepherd Dog - German 4
Retriever - Golden 3
Domestic Mediumhair 3
Terrier - Yorkshire 3
Holstein-Friesian also known as Holstein 3

Associated Drugs

Maropitant Citrate 12
Milbemycin Oxime + Spinosad 8
Buprenorphine 8
Afoxolaner 8
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 8
Fluid Therapy 7
Ivermectin + Pyrantel As Pamoate Salt 6
Cefovecin 6
Moxidectin 6
Enrofloxacin 6
Isoflurane 5
Milbemycin Oxime + Praziquantel 5
Frunevetmab 5
Bedinvetmab 5
Carprofen 4
Robenacoxib 4
Cefovecin Sodium 4
Dexmedetomidine 4
Fluralaner 13.64% 12-Week Chew 4
Gabapentin 4

Sunken eyes Reaction Insights

119 reports name Sunken eyes; 42 recorded a death outcome (35.3% of reported events, not a population-level mortality rate). VeDDRA code: 2273.

By species: Dog (75 reports), Cat (37 reports), Cattle (6 reports). By breed: Domestic Shorthair (12), Retriever - Labrador (10), Pit Bull (6).

Most co-reported drugs: Maropitant Citrate (12 reports), Milbemycin Oxime + Spinosad (8 reports), Buprenorphine (8 reports), Afoxolaner (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.