Reaction profile

The FDA adverse-event record for sunken eyes

128 FDA adverse-event reports reference sunken eyes (VeDDRA 2273). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1271 of 2,481
by report volume (all reactions)
128
reports citing this reaction
35.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Sunken eyes has 128 reports now versus 125 in that prior snapshot: 3 more (2.4%).

Report change
+3
Death-coded reports
+1
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Sunken eyes changes

FDA AER · VeDDRA plate

Code 2273 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 128 reports
  • DEATH-HOT 35.2%
  • MID-PACK #1271/2481
  • PHOTO-FINISH Chemosis
  • SPECIES-DOG Dog · 80
  • DRUG-LEAD Maropitant Citrate · 15
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Chemosis (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Sunken eyes

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Chemosis · near128Injection site skin c… · near128Sunken eyes · this reaction128Suspected infectious… · near128Cyst NOS · near127Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Sunken eyes

Sunken eyes: high death-coded share in the FDA AER plate

Signature read: Sunken eyes's 35.2% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 45 of 128 reports (35.2% of named reports). Nearest volume peer: Chemosis (±0 reports). Lead species Dog (80). Lead co-reported drug Maropitant Citrate (15).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 80
Cat 40
Cattle 7
Horse 1

Breeds Most Affected

Domestic Shorthair 15
Retriever - Labrador 10
Pit Bull 6
Domestic Longhair 6
Shepherd Dog - German 5
Boxer (German Boxer) 4
Holstein-Friesian also known as Holstein 4
Akita 4
Retriever - Golden 3
Domestic Mediumhair 3

Associated Drugs

Maropitant Citrate 15
Milbemycin Oxime + Spinosad 8
Buprenorphine 8
Afoxolaner 8
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 8
Cefovecin 7
Moxidectin 7
Fluid Therapy 7
Frunevetmab 7
Carprofen 6
Ivermectin + Pyrantel As Pamoate Salt 6
Enrofloxacin 6
Isoflurane 5
Milbemycin Oxime + Praziquantel 5
Bedinvetmab 5
Robenacoxib 4
Cefovecin Sodium 4
Midazolam 4
Metronidazole 4
Dexmedetomidine 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Sunken eyes, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (128 here).

Similar death-coded share

Nearest other reactions by death-coded share (35.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Sunken eyes (#1271 of 2,481 by report volume); death-coded 35.2%. PlainBreed reaction plate · death-coded share stamp 35.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →