Reaction profile

The FDA adverse-event record for elevated lactic acid dehydrogenase (ldh)

65 FDA adverse-event reports reference elevated lactic acid dehydrogenase (ldh) (VeDDRA 2269). See the species, breeds, and drugs most associated with it below.

65
reports citing this reaction
35.4%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
65
Total Reports
23
Deaths
35.4%
Death Rate

Species Most Affected

Dog 41
Horse 20
Cat 2
Cattle 1
Human 1

Breeds Most Affected

Quarter Horse 7
Crossbred Canine/dog 4
Schnauzer (unspecified) 3
Thoroughbred 3
Horse (unknown) 3
Retriever - Labrador 2
Retriever - Golden 2
Pug 2
Deutsche Dogge, Great Dane 2
Siberian Husky 2

Associated Drugs

Carprofen 10
Moxidectin 7
Firocoxib 6
Pergolide Mesylate 5
Polysulfated Glycosaminoglycan 5
Fluralaner Chew Tablets 4
Gabapentin 4
Maropitant Citrate 3
Diphenhydramine Hcl 3
Maropitant 2
Famotidine 2
Milbemycin Oxime + Spinosad 2
Oclacitinib Maleate 2
Hydromorphone 2
Propofol 2
Isoflurane 2
Tramadol 2
Monensin Sodium 2
Omeprazole 2
Injectable Analgesic 2

Elevated lactic acid dehydrogenase (LDH) Reaction Insights

65 reports name Elevated lactic acid dehydrogenase (LDH); 23 recorded a death outcome (35.4% of reported events, not a population-level mortality rate). VeDDRA code: 2269.

By species: Dog (41 reports), Horse (20 reports), Cat (2 reports). By breed: Quarter Horse (7), Crossbred Canine/dog (4), Schnauzer (unspecified) (3).

Most co-reported drugs: Carprofen (10 reports), Moxidectin (7 reports), Firocoxib (6 reports), Pergolide Mesylate (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.