Reaction profile

The FDA adverse-event record for renal disorder nos

1,613 FDA adverse-event reports reference renal disorder nos (VeDDRA 719). See the species, breeds, and drugs most associated with it below.

1,613
reports citing this reaction
41.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,613
Total Reports
666
Deaths
41.3%
Death Rate

Species Most Affected

Dog 1,145
Cat 411
Cattle 17
Horse 13
Chicken 5
Human 5
Sheep 3
Other Birds 3
Goat 3
Pig 2

Breeds Most Affected

Domestic Shorthair 205
Retriever - Labrador 118
Dog (unknown) 84
Crossbred Canine/dog 78
Terrier - Yorkshire 46
Domestic (unspecified) 44
Chihuahua 43
Shih Tzu 41
Retriever - Golden 40
Beagle 36

Associated Drugs

Milbemycin Oxime + Spinosad 155
Carprofen 153
Maropitant Citrate 137
Oclacitinib Maleate 95
Spinosad 78
Bedinvetmab 76
Trilostane 73
Gabapentin 71
Cefovecin 70
Meloxicam 69
Afoxolaner 63
Fluralaner Chew Tablets 50
Grapiprant 46
Deracoxib 45
Enrofloxacin 44
Tramadol 44
Selamectin 43
Famotidine 43
Buprenorphine 43
Prednisone 42

Renal disorder NOS Reaction Insights

1,613 reports name Renal disorder NOS; 666 recorded a death outcome (41.3% of reported events, not a population-level mortality rate). VeDDRA code: 719.

By species: Dog (1,145 reports), Cat (411 reports), Cattle (17 reports). By breed: Domestic Shorthair (205), Retriever - Labrador (118), Dog (unknown) (84).

Most co-reported drugs: Milbemycin Oxime + Spinosad (155 reports), Carprofen (153 reports), Maropitant Citrate (137 reports), Oclacitinib Maleate (95 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.