Reaction profile

The FDA adverse-event record for unrelated death

648 FDA adverse-event reports reference unrelated death (VeDDRA 2110). See the species, breeds, and drugs most associated with it below.

648
reports citing this reaction
98.5%
death-coded share
Dog
most-affected species
Tiletamine Hcl, Zolazepam Hcl
most-associated drug
Verify with FDA CVM →
648
Total Reports
638
Deaths
98.5%
Death Rate

Species Most Affected

Dog 373
Cattle 150
Cat 75
Horse 18
Pig 6
Sheep 6
Mouse 5
Rabbit 4
Other Birds 2
Chicken 2

Breeds Most Affected

Dog (unknown) 109
Mixed (Cattle) 87
Retriever - Labrador 36
Cat (unknown) 26
Cattle (other) 23
Domestic Shorthair 23
Holstein-Friesian also known as Holstein 23
Shepherd Dog - German 20
Crossbred Canine/dog 14
Retriever - Golden 14

Associated Drugs

Tiletamine Hcl, Zolazepam Hcl 67
Tulathromycin 61
Milbemycin Oxime + Spinosad 48
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 46
Ivermectin + Pyrantel As Pamoate Salt 43
Ceftiofur Crystalline Free Acid 42
Pentobarbital/Phenytoin Inj 33
Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia 25
Spinosad 24
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D; Bovine Viral D 19
Butorphanol 19
Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus 19
Ketamine Hydrochloride 19
Tiletamine Hcl;Zolazapam Hcl 19
Acepromazine 18
Afoxolaner 17
Acepromazine Maleate 16
Dexmedetomidine 16
Doramectin 14
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D;Bovine Viral Di 13

Unrelated death Reaction Insights

648 reports name Unrelated death; 638 recorded a death outcome (98.5% of reported events, not a population-level mortality rate). VeDDRA code: 2110.

By species: Dog (373 reports), Cattle (150 reports), Cat (75 reports). By breed: Dog (unknown) (109), Mixed (Cattle) (87), Retriever - Labrador (36).

Most co-reported drugs: Tiletamine Hcl, Zolazepam Hcl (67 reports), Tulathromycin (61 reports), Milbemycin Oxime + Spinosad (48 reports), Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn (46 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.