Reaction profile

The FDA adverse-event record for respiratory arrest

673 FDA reports name respiratory arrest, a high-volume reaction in the CVM extract (VeDDRA 831). Plate stamps and neighbourhood peers follow.

#529 of 2,481
by report volume (all reactions)
673
reports citing this reaction
76.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Respiratory arrest has 673 reports now versus 665 in that prior snapshot: 8 more (1.2%).

Report change
+8
Death-coded reports
+4
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Respiratory arrest changes

FDA AER · VeDDRA plate

Code 831 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 673 reports
  • DEATH-HOT 76.7%
  • UPPER-Q #529/2481
  • PHOTO-FINISH Involuntary defecation
  • SPECIES-DOG Dog · 449
  • DRUG-LEAD Isoflurane · 117
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Involuntary defecation (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Respiratory arrest

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Other ear disorder NOS · near675Involuntary defecation · near673Respiratory arrest · this re…673Unrelated death · near673Lack of efficacy (pro… · near670Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Respiratory arrest

Respiratory arrest: high death-coded share in the FDA AER plate

Signature read: 516 death-coded reports is a heavy tail count for Respiratory arrest in the CVM extract. Report volume is upper-third scale: 673 named reports in the openFDA extract. Death-coded share is upper-third: 516 of 673 reports (76.7% of named reports). Nearest volume peer: Involuntary defecation (±0 reports). Lead species Dog (449). Lead co-reported drug Isoflurane (117).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 449
Cat 204
Rabbit 5
Horse 4
Human 2
Rat 1
Fish 1
Guinea Pig 1
Mouse 1
Pig 1

Breeds Most Affected

Domestic Shorthair 120
Chihuahua 38
Retriever - Labrador 34
Terrier - Yorkshire 29
Pug 21
Cat (unknown) 21
Spitz - German Pomeranian 19
Domestic Longhair 18
Shih Tzu 18
Dog (unknown) 16

Associated Drugs

Isoflurane 117
Dexmedetomidine Hydrochloride 95
Butorphanol 89
Maropitant Citrate 89
Ketamine 62
Buprenorphine 59
Propofol 51
Cefovecin 50
Carprofen 47
Dexmedetomidine 47
Epinephrine 43
Butorphanol Tartrate 43
Moxidectin 40
Atropine 35
Dexamethasone 35
Atipamezole Hydrochloride 34
Midazolam 32
Milbemycin Oxime + Spinosad 30
Diazepam 27
Gabapentin 26

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Respiratory arrest, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (76.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Respiratory arrest (#529 of 2,481 by report volume); death-coded 76.7%. PlainBreed reaction plate · death-coded report count stamp 516 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →