Reaction profile

The FDA adverse-event record for other ear disorder nos

654 FDA adverse-event reports reference other ear disorder nos (VeDDRA 1667). See the species, breeds, and drugs most associated with it below.

654
reports citing this reaction
5.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
654
Total Reports
35
Deaths
5.4%
Death Rate

Species Most Affected

Dog 555
Cat 87
Human 5
Cattle 5
Horse 2

Breeds Most Affected

Retriever - Labrador 66
Domestic Shorthair 49
Crossbred Canine/dog 40
Shepherd Dog - German 30
Retriever - Golden 29
Shih Tzu 23
Boxer (German Boxer) 22
Chihuahua 21
Pit Bull 19
Terrier - Yorkshire 16

Associated Drugs

Milbemycin Oxime + Spinosad 149
Betamethasone + Florfenicol + Terbinafine 67
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 64
Milbemycin Oxime + Praziquantel 43
Afoxolaner 34
Oclacitinib Maleate 32
Spinosad 30
Carprofen 27
Maropitant Citrate 25
Gabapentin 24
Prednisone 23
Genta/Momet/Clotrim Ear Oint 20
Selamectin 19
Enrofloxacin 19
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 19
Ear Cleaner (Unknown) 18
Rabies Vaccine 17
Miconazole + Polymyxin B + Prednisolone 17
Ketoconazole 14
Milbemycin Oxime 13

Other ear disorder NOS Reaction Insights

654 reports name Other ear disorder NOS; 35 recorded a death outcome (5.4% of reported events, not a population-level mortality rate). VeDDRA code: 1667.

By species: Dog (555 reports), Cat (87 reports), Human (5 reports). By breed: Retriever - Labrador (66), Domestic Shorthair (49), Crossbred Canine/dog (40).

Most co-reported drugs: Milbemycin Oxime + Spinosad (149 reports), Betamethasone + Florfenicol + Terbinafine (67 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (64 reports), Milbemycin Oxime + Praziquantel (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.