Reaction profile

The FDA adverse-event record for uncomfortable

1,605 FDA adverse-event reports reference uncomfortable (VeDDRA 2499). See the species, breeds, and drugs most associated with it below.

1,605
reports citing this reaction
12.5%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
1,605
Total Reports
200
Deaths
12.5%
Death Rate

Species Most Affected

Dog 1,312
Cat 224
Horse 52
Cattle 11
Unknown 2
Chicken 1
Sheep 1
Ferret 1
Deer 1

Breeds Most Affected

Retriever - Labrador 143
Domestic Shorthair 124
Crossbred Canine/dog 83
Shepherd Dog - German 59
Chihuahua 58
Retriever - Golden 57
Dog (unknown) 42
Shih Tzu 42
Terrier - Yorkshire 41
Boxer (German Boxer) 33

Associated Drugs

Bedinvetmab 150
Gabapentin 143
Carprofen 99
Prednisone 92
Afoxolaner 90
Maropitant Citrate 87
Trilostane 80
Melarsomine Dihydrochloride 74
Milbemycin Oxime + Spinosad 65
Ivermectin + Pyrantel As Pamoate Salt 64
Buprenorphine 63
Oclacitinib Maleate 61
Fluralaner Chew Tablets 60
Moxidectin 60
Grapiprant 55
Fluralaner 13.64% 12-Week Chew 55
Tigilanol Tiglate 55
Diphenhydramine 54
Pyrantel Pamoate;Sarolaner 54
Polysulfated Glycosaminoglycan 49

Uncomfortable Reaction Insights

1,605 reports name Uncomfortable; 200 recorded a death outcome (12.5% of reported events, not a population-level mortality rate). VeDDRA code: 2499.

By species: Dog (1,312 reports), Cat (224 reports), Horse (52 reports). By breed: Retriever - Labrador (143), Domestic Shorthair (124), Crossbred Canine/dog (83).

Most co-reported drugs: Bedinvetmab (150 reports), Gabapentin (143 reports), Carprofen (99 reports), Prednisone (92 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.