Reaction profile

The FDA adverse-event record for laceration

158 FDA adverse-event reports reference laceration (VeDDRA 2509). See the species, breeds, and drugs most associated with it below.

158
reports citing this reaction
13.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
158
Total Reports
21
Deaths
13.3%
Death Rate

Species Most Affected

Dog 98
Human 20
Cat 19
Cattle 7
Horse 6
Pig 3
Unknown 3
Chicken 2

Breeds Most Affected

Unknown 23
Retriever - Labrador 15
Domestic Shorthair 13
Dog (unknown) 8
Retriever - Golden 6
Greyhound 6
Crossbred Canine/dog 5
Collie - Border 5
Shih Tzu 5
Shepherd Dog - German 4

Associated Drugs

Milbemycin Oxime + Spinosad 27
Milbemycin Oxime + Praziquantel 20
Imidacloprid + Moxidectin 18
Afoxolaner 12
Buprenorphine 9
Gabapentin 8
Moxidectin 8
Robenacoxib 8
Fluralaner Chew Tablets 7
Lotilaner 7
Bedinvetmab 7
Dexmedetomidine 6
Carprofen 6
Nitenpyram 6
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine 6
Tylosin Phosphate 6
Trilostane 5
Fenbendazole 5
Selamectin 4
Ketamine 4

Laceration Reaction Insights

158 reports name Laceration; 21 recorded a death outcome (13.3% of reported events, not a population-level mortality rate). VeDDRA code: 2509.

By species: Dog (98 reports), Human (20 reports), Cat (19 reports). By breed: Unknown (23), Retriever - Labrador (15), Domestic Shorthair (13).

Most co-reported drugs: Milbemycin Oxime + Spinosad (27 reports), Milbemycin Oxime + Praziquantel (20 reports), Imidacloprid + Moxidectin (18 reports), Afoxolaner (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.