Reaction profile

The FDA adverse-event record for tubes, leaking

3,509 FDA reports name tubes, leaking, a high-volume reaction in the CVM extract (VeDDRA 99029). Plate stamps and neighbourhood peers follow.

#131 of 2,481
by report volume (all reactions)
3,509
reports citing this reaction
0.1%
death-coded share
Unknown
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Tubes, Leaking has 3,509 reports now versus 3,430 in that prior snapshot: 79 more (2.3%).

Report change
+79
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Tubes, Leaking changes

FDA AER · VeDDRA plate

Code 99029 VOL-MID

VOL-MID · DEATH-RARE · TOP-DECILE · PHOTO-FINISH · SPECIES-UNKNOWN · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 3,509 reports
  • DEATH-RARE 0.1%
  • TOP-DECILE #131/2481
  • PHOTO-FINISH Hypoalbuminaemia
  • SPECIES-UNKNOWN Unknown · 3,257
  • DRUG-LEAD Selamectin · 730
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hypoalbuminaemia (±21 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Tubes, Leaking

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Tubes, Leaking · this reacti…3509Hypoalbuminaemia · near3488Convulsion · near3461Dilated pupils · near3461Lateral recumbency · near3455Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Tubes, Leaking

Tubes, Leaking: low death-coded share in the FDA AER plate

Signature read: 3,509 reports place Tubes, Leaking in the upper third of FDA AER volume (#131 of 2,481). Report volume is upper-third scale: 3,509 named reports in the openFDA extract. Death-coded share is lower-third: 2 of 3,509 reports (0.1% of named reports). Nearest volume peer: Hypoalbuminaemia (±21 reports). Lead species Unknown (3,257). Lead co-reported drug Selamectin (730).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Selamectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 3,257
Human 218
Cat 19
Dog 14
Cattle 1

Breeds Most Affected

Unknown 3,475
Domestic (unspecified) 5
Cat (unknown) 4
Domestic Shorthair 4
Crossbred Canine/dog 2
Dog (unknown) 2
Domestic Longhair 2
Retriever - Labrador 1
Spitz - German Pomeranian 1
Spaniel - Cocker American 1

Associated Drugs

Selamectin 730
Fluralaner Spot-On Solution 558
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 439
Cyclosporin Ointment 383
Selamectin;Sarolaner 295
Mirtazapine 236
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 194
Milbemycin Oxime 111
Milbemycin Oxime Solution 86
Imidacloprid + Moxidectin 75
Fluralaner/Moxidectin Spot-On 66
Cyclosporine 40
Emodepside + Praziquantel 33
Omeprazole 21
Genta/Betamet/Clotrim Ear Oint 16
Cephapirin Benzathine 12
Ivermectin 11
Buprenorphine 11
Triamcinolone Acetonide 0.015% 10
Omeprazole 37% Oral Paste 10

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Tubes, Leaking, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (3,509 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Tubes, Leaking (#131 of 2,481 by report volume); death-coded 0.1%. PlainBreed reaction plate · report volume stamp 3,509 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →