Reaction profile

The FDA adverse-event record for convulsion

3,430 FDA adverse-event reports reference convulsion (VeDDRA 642). See the species, breeds, and drugs most associated with it below.

3,430
reports citing this reaction
21.0%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
3,430
Total Reports
721
Deaths
21.0%
Death Rate

Species Most Affected

Dog 2,909
Cat 411
Horse 43
Cattle 34
Goat 4
Rabbit 4
Pig 4
Sheep 4
Other 3
Human 3

Breeds Most Affected

Crossbred Canine/dog 492
Retriever - Labrador 246
Domestic (unspecified) 241
Chihuahua 142
Dog (unknown) 125
Terrier - Yorkshire 119
Shih Tzu 98
Boxer (German Boxer) 92
Retriever - Golden 79
Dachshund (unspecified) 77

Associated Drugs

Spinosad 534
Selamectin 205
Carprofen 198
Ivermectin, Pyrantel 176
Milbemycin 125
Spinosad, Milbemycin 105
Cyclosporine 94
Cefovecin Sodium 92
Afoxolaner 92
Milbemycin Oxime + Spinosad 86
Moxidectin 76
Milbemycin, Lufenuron 73
Meloxicam 73
Dexmedetomidine Hydrochloride 64
Fluralaner Chew Tablets 64
Propofol 62
Ketamine Hydrochloride 57
Firocoxib 57
Maropitant 50
Ivermectin 48

Convulsion Reaction Insights

3,430 reports name Convulsion; 721 recorded a death outcome (21.0% of reported events, not a population-level mortality rate). VeDDRA code: 642.

By species: Dog (2,909 reports), Cat (411 reports), Horse (43 reports). By breed: Crossbred Canine/dog (492), Retriever - Labrador (246), Domestic (unspecified) (241).

Most co-reported drugs: Spinosad (534 reports), Selamectin (205 reports), Carprofen (198 reports), Ivermectin, Pyrantel (176 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.