Reaction profile

The FDA adverse-event record for underfilling, container

6,043 FDA adverse-event reports reference underfilling, container (VeDDRA 99959). See the species, breeds, and drugs most associated with it below.

6,043
reports citing this reaction
0.0%
death-coded share
Unknown
most-affected species
Fluralaner Spot-On Solution
most-associated drug
Verify with FDA CVM →
6,043
Total Reports
2
Deaths
0.0%
Death Rate

Species Most Affected

Unknown 6,006
Cat 17
Dog 15
Horse 3
Human 2

Breeds Most Affected

Unknown 6,008
Domestic Shorthair 7
Domestic Longhair 4
Cat (unknown) 3
Dog (unknown) 3
Domestic Mediumhair 2
Retriever - Labrador 2
Chihuahua 2
Shepherd Dog - Australian 2
Quarter Horse 1

Associated Drugs

Fluralaner Spot-On Solution 731
Sarolaner 454
Pyrantel Pamoate;Sarolaner 425
Cyclosporin Ointment 424
Afoxolaner 207
Oclacitinib Maleate 184
Fluralaner Chew Tablets 169
Fluralaner/Moxidectin Spot-On 162
Fluralaner 13.64% 12-Week Chew 156
Ivermectin + Pyrantel As Pamoate Salt 152
Carprofen 132
Moxidectin 109
Trilostane 101
Selamectin 95
Lufenuron + Milbemycin Oxime 92
Maropitant Citrate 91
Insulin Injectable Vial 79
Mirtazapine 76
Pimobendan 74
Genta/Momet/Clotrim Ear Oint 71

Underfilling, Container Reaction Insights

6,043 reports name Underfilling, Container; 2 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 99959.

By species: Unknown (6,006 reports), Cat (17 reports), Dog (15 reports). By breed: Unknown (6,008), Domestic Shorthair (7), Domestic Longhair (4).

Most co-reported drugs: Fluralaner Spot-On Solution (731 reports), Sarolaner (454 reports), Pyrantel Pamoate;Sarolaner (425 reports), Cyclosporin Ointment (424 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.