Reaction profile

The FDA adverse-event record for tremor of limb

704 FDA reports name tremor of limb, a high-volume reaction in the CVM extract (VeDDRA 1853). Plate stamps and neighbourhood peers follow.

#510 of 2,481
by report volume (all reactions)
704
reports citing this reaction
6.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Tremor of limb has 704 reports now versus 695 in that prior snapshot: 9 more (1.3%).

Report change
+9
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Tremor of limb changes

FDA AER · VeDDRA plate

Code 1853 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 704 reports
  • DEATH-PAR 6.7%
  • UPPER-Q #510/2481
  • PHOTO-FINISH Excessive chewing, li…
  • SPECIES-DOG Dog · 637
  • DRUG-LEAD Milbemycin Oxime… · 98
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Excessive chewing, licking and/or grooming (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Tremor of limb

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site hair… · near709Excessive chewing, li… · near704Tremor of limb · this reacti…704Injection site necros… · near703Epistaxis · near699Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Tremor of limb

Tremor of limb: low death-coded share in the FDA AER plate

Signature read: 704 reports place Tremor of limb in the upper third of FDA AER volume (#510 of 2,481). Report volume is upper-third scale: 704 named reports in the openFDA extract. Death-coded share is lower-third: 47 of 704 reports (6.7% of named reports). Nearest volume peer: Excessive chewing, licking and/or grooming (±0 reports). Lead species Dog (637). Lead co-reported drug Milbemycin Oxime + Spinosad (98).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 637
Cat 65
Hamster 1
Horse 1

Breeds Most Affected

Retriever - Labrador 62
Domestic Shorthair 49
Crossbred Canine/dog 42
Retriever - Golden 40
Terrier - Yorkshire 31
Shih Tzu 23
Dog (unknown) 23
Chihuahua 21
Shepherd Dog - Australian 19
Terrier - Jack Russell 17

Associated Drugs

Milbemycin Oxime + Spinosad 98
Afoxolaner 98
Pyrantel Pamoate;Sarolaner 93
Sarolaner 69
Fluralaner 13.64% 12-Week Chew 44
Fluralaner Chew Tablets 31
Bedinvetmab 31
Ivermectin + Pyrantel As Pamoate Salt 29
Carprofen 20
Oclacitinib Maleate 18
Spinosad 16
Selamectin 16
Moxidectin 15
Milbemycin Oxime + Praziquantel 15
Lotilaner 15
Maropitant Citrate 13
Cyclosporine A 12
Fluralaner Spot-On Solution 12
Gabapentin 10
Grapiprant 10

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Tremor of limb, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (6.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Tremor of limb (#510 of 2,481 by report volume); death-coded 6.7%. PlainBreed reaction plate · report volume stamp 704 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →