Reaction profile

The FDA adverse-event record for tremor of limb

684 FDA adverse-event reports reference tremor of limb (VeDDRA 1853). See the species, breeds, and drugs most associated with it below.

684
reports citing this reaction
6.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
684
Total Reports
47
Deaths
6.9%
Death Rate

Species Most Affected

Dog 618
Cat 64
Hamster 1
Horse 1

Breeds Most Affected

Retriever - Labrador 59
Domestic Shorthair 48
Crossbred Canine/dog 42
Retriever - Golden 39
Terrier - Yorkshire 31
Shih Tzu 23
Dog (unknown) 23
Chihuahua 21
Terrier - Jack Russell 17
Boxer (German Boxer) 17

Associated Drugs

Milbemycin Oxime + Spinosad 98
Afoxolaner 94
Pyrantel Pamoate;Sarolaner 92
Sarolaner 69
Fluralaner 13.64% 12-Week Chew 40
Fluralaner Chew Tablets 31
Ivermectin + Pyrantel As Pamoate Salt 29
Bedinvetmab 27
Carprofen 18
Oclacitinib Maleate 17
Spinosad 16
Selamectin 16
Moxidectin 15
Cyclosporine A 12
Milbemycin Oxime + Praziquantel 12
Fluralaner Spot-On Solution 12
Maropitant Citrate 12
Lotilaner 11
Gabapentin 10
Milbemycin Oxime 9

Tremor of limb Reaction Insights

684 reports name Tremor of limb; 47 recorded a death outcome (6.9% of reported events, not a population-level mortality rate). VeDDRA code: 1853.

By species: Dog (618 reports), Cat (64 reports), Hamster (1 reports). By breed: Retriever - Labrador (59), Domestic Shorthair (48), Crossbred Canine/dog (42).

Most co-reported drugs: Milbemycin Oxime + Spinosad (98 reports), Afoxolaner (94 reports), Pyrantel Pamoate;Sarolaner (92 reports), Sarolaner (69 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.