Reaction profile

The FDA adverse-event record for transient blindness

60 FDA adverse-event reports reference transient blindness (VeDDRA 1850). See the species, breeds, and drugs most associated with it below.

60
reports citing this reaction
6.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
60
Total Reports
4
Deaths
6.7%
Death Rate

Species Most Affected

Dog 39
Cat 16
Cattle 2
Cockatiel 1
Fox 1
Horse 1

Breeds Most Affected

Domestic Shorthair 10
Chihuahua 5
Unknown 4
Retriever - Labrador 3
Pekingese 3
Terrier - Yorkshire 2
Shih Tzu 2
Siamese 2
Collie - Border 2
Shepherd Dog - Australian 2

Associated Drugs

Milbemycin Oxime + Spinosad 10
Ivermectin 8
Spinosad 4
Imidacloprid + Moxidectin 4
Butorphanol 4
Trilostane 3
Fluralaner Chew Tablets 3
Buprenorphine 3
Ketamine 3
Isoflurane 3
Prednisone 2
Tiletamine Hcl; Zolazapam Hcl 2
Oclacitinib 2
Afoxolaner 2
Alfaxalone 2
Maropitant Citrate 2
Moxidectin 2
Lotilaner 2
Fluralaner 13.64% 12-Week Chew 2
Dexmedetomidine 2

Transient blindness Reaction Insights

60 reports name Transient blindness; 4 recorded a death outcome (6.7% of reported events, not a population-level mortality rate). VeDDRA code: 1850.

By species: Dog (39 reports), Cat (16 reports), Cattle (2 reports). By breed: Domestic Shorthair (10), Chihuahua (5), Unknown (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (10 reports), Ivermectin (8 reports), Spinosad (4 reports), Imidacloprid + Moxidectin (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.