Reaction profile

The FDA adverse-event record for toxicity

Name: TOXICITY - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

53 FDA reports name toxicity, a lower-volume reaction in the CVM extract (VeDDRA 99359). Plate stamps and neighbourhood peers follow.

#1714 of 2,481
by report volume (all reactions): 53
reports citing this reaction: 62.3%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. TOXICITY has 53 reports now versus 53 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to TOXICITY changes

FDA AER · VeDDRA plate

Code 99359 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-LOW 53 reports
DEATH-HOT 62.3%
MID-PACK #1714/2481
PHOTO-FINISH Bloody foam in mouth…
SPECIES-DOG Dog · 26
DRUG-LEAD Carprofen · 8
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Bloody foam in mouth and nose (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around TOXICITY

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around TOXICITY

TOXICITY: high death-coded share in the FDA AER plate

Signature read: TOXICITY's 62.3% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 53 named reports in the openFDA extract. Death-coded share is upper-third: 33 of 53 reports (62.3% of named reports). Nearest volume peer: Bloody foam in mouth and nose (±0 reports). Lead species Dog (26). Lead co-reported drug Carprofen (8).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 26

Cattle 14

Cat 8

Turtle 1

Sheep 1

Horse 1

Unknown 1

Donkey 1

Breeds Most Affected

Retriever - Labrador 7

Unknown 6

Cattle (unknown) 5

Holstein-Friesian also known as Holstein 4

Crossbred Bovine/Cattle 3

Terrier - West Highland White 3

Domestic Shorthair 3

Cat (unknown) 2

Newfoundland 1

Komondor 1

Associated Drugs

Carprofen 8

Monensin 6

Ivermectin 4

Monensin Sodium 4

Deracoxib 3

Selamectin 3

Meloxicam 2

Clindamycin Hydrochloride 2

Phenobarbital 1

Ivermectin, Pyrantel 1

Amoxicillin, Clavulanate 1

Dirlotapide 1

Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1

Maropitant Citrate 1

Buprenorphine 1

Ampicillin 1

Enrofloxacin 1

Doxycycline 1

Vitamin K1 1

Dolasetron 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for TOXICITY, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (53 here).

Bloody foam in mouth and nose 53 Decreased skin turgor 53 Easily startled 53 Footpad disorder NOS 53

Similar death-coded share

Nearest other reactions by death-coded share (62.3% here), distinct from the volume row.

PR-LYMPH NODE(S), LESION(S) 62.3% Lung oedema 62.2% Splenic neoplasm 62.3% Leukaemia 62.4%

What to do with this reaction

Compare TOXICITY's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for TOXICITY (#1714 of 2,481 by report volume); death-coded 62.3%. PlainBreed reaction plate · death-coded share stamp 62.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →