Reaction profile

The FDA adverse-event record for toxicity

54 FDA adverse-event reports reference toxicity (VeDDRA 99359). See the species, breeds, and drugs most associated with it below.

54
reports citing this reaction
61.1%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
54
Total Reports
33
Deaths
61.1%
Death Rate

Species Most Affected

Dog 27
Cattle 14
Cat 8
Turtle 1
Sheep 1
Horse 1
Unknown 1
Donkey 1

Breeds Most Affected

Retriever - Labrador 7
Unknown 6
Cattle (unknown) 5
Holstein-Friesian also known as Holstein 4
Crossbred Bovine/Cattle 3
Terrier - West Highland White 3
Domestic Shorthair 3
Cat (unknown) 2
Newfoundland 1
Komondor 1

Associated Drugs

Carprofen 8
Monensin 6
Ivermectin 4
Monensin Sodium 4
Deracoxib 3
Selamectin 3
Meloxicam 2
Phenobarbital 2
Potassium Bromide 2
Clindamycin Hydrochloride 2
Ivermectin, Pyrantel 1
Amoxicillin, Clavulanate 1
Dirlotapide 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Maropitant Citrate 1
Buprenorphine 1
Ampicillin 1
Enrofloxacin 1
Doxycycline 1
Vitamin K1 1

TOXICITY Reaction Insights

54 reports name TOXICITY; 33 recorded a death outcome (61.1% of reported events, not a population-level mortality rate). VeDDRA code: 99359.

By species: Dog (27 reports), Cattle (14 reports), Cat (8 reports). By breed: Retriever - Labrador (7), Unknown (6), Cattle (unknown) (5).

Most co-reported drugs: Carprofen (8 reports), Monensin (6 reports), Ivermectin (4 reports), Monensin Sodium (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.