Reaction profile

The FDA adverse-event record for congestive heart failure

402 FDA adverse-event reports reference congestive heart failure (VeDDRA 2429). See the species, breeds, and drugs most associated with it below.

402
reports citing this reaction
52.5%
death-coded share
Dog
most-affected species
Pimobendan
most-associated drug
Verify with FDA CVM →
402
Total Reports
211
Deaths
52.5%
Death Rate

Species Most Affected

Dog 320
Cat 74
Cattle 5
Rabbit 1
Other Birds 1
Horse 1

Breeds Most Affected

Domestic Shorthair 43
Chihuahua 34
Crossbred Canine/dog 24
Dog (unknown) 21
Spaniel - King Charles Cavalier 19
Shih Tzu 19
Maltese 14
Dachshund (unspecified) 14
Spitz - German Pomeranian 13
Terrier - Yorkshire 13

Associated Drugs

Pimobendan 55
Milbemycin Oxime + Spinosad 47
Furosemide 32
Trilostane 30
Ivermectin + Pyrantel As Pamoate Salt 29
Bedinvetmab 27
Moxidectin 19
Fluralaner 13.64% 12-Week Chew 17
Cefovecin 16
Afoxolaner 16
Spinosad 15
Gabapentin 15
Frunevetmab 15
Maropitant Citrate 14
Prednisone 14
Milbemycin Oxime + Praziquantel 14
Fluralaner Chew Tablets 13
Pyrantel Pamoate;Sarolaner 13
Buprenorphine 12
Milbemycin Oxime 11

Congestive heart failure Reaction Insights

402 reports name Congestive heart failure; 211 recorded a death outcome (52.5% of reported events, not a population-level mortality rate). VeDDRA code: 2429.

By species: Dog (320 reports), Cat (74 reports), Cattle (5 reports). By breed: Domestic Shorthair (43), Chihuahua (34), Crossbred Canine/dog (24).

Most co-reported drugs: Pimobendan (55 reports), Milbemycin Oxime + Spinosad (47 reports), Furosemide (32 reports), Trilostane (30 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.