Reaction profile

The FDA adverse-event record for thyroid gland disorder nos

183 FDA adverse-event reports reference thyroid gland disorder nos (VeDDRA 405). See the species, breeds, and drugs most associated with it below.

183
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
183
Total Reports
50
Deaths
27.3%
Death Rate

Species Most Affected

Dog 140
Cat 38
Human 4
Horse 1

Breeds Most Affected

Domestic Shorthair 23
Retriever - Labrador 17
Boxer (German Boxer) 10
Chihuahua 10
Terrier - Boston 9
Retriever - Golden 8
Dog (unknown) 8
Domestic Longhair 6
Maltese 6
Beagle 5

Associated Drugs

Milbemycin Oxime + Spinosad 36
Oclacitinib Maleate 22
Spinosad 20
Trilostane 15
Carprofen 10
Maropitant Citrate 10
Imidacloprid + Moxidectin 7
Selamectin 7
Fluralaner Chew Tablets 7
Afoxolaner 6
Levothyroxine Sodium 5
Telmisartan 5
Enrofloxacin 4
Vitamin B12 4
Moxidectin 4
Ivermectin 4
Ivermectin + Pyrantel As Pamoate Salt 4
Fluralaner 13.64% 12-Week Chew 4
Cefovecin 3
Meloxicam 3

Thyroid gland disorder NOS Reaction Insights

183 reports name Thyroid gland disorder NOS; 50 recorded a death outcome (27.3% of reported events, not a population-level mortality rate). VeDDRA code: 405.

By species: Dog (140 reports), Cat (38 reports), Human (4 reports). By breed: Domestic Shorthair (23), Retriever - Labrador (17), Boxer (German Boxer) (10).

Most co-reported drugs: Milbemycin Oxime + Spinosad (36 reports), Oclacitinib Maleate (22 reports), Spinosad (20 reports), Trilostane (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.