Reaction profile

The FDA adverse-event record for thyroid gland disorder nos

185 FDA adverse-event reports reference thyroid gland disorder nos (VeDDRA 405). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1079 of 2,481
by report volume (all reactions)
185
reports citing this reaction
27.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Thyroid gland disorder NOS has 185 reports now versus 185 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Thyroid gland disorder NOS changes

FDA AER · VeDDRA plate

Code 405 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 185 reports
  • DEATH-HOT 27.0%
  • MID-PACK #1079/2481
  • PHOTO-FINISH Coughing up blood
  • SPECIES-DOG Dog · 142
  • DRUG-LEAD Milbemycin Oxime… · 36
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Coughing up blood (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Thyroid gland disorder NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Coughing up blood · near185Epidermal collarette · near185Peripheral nervous sy… · near185Thyroid gland disorde… · thi…185BANDS(NEUTROPHILS) HI… · near184Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Thyroid gland disorder NOS

Thyroid gland disorder NOS: high death-coded share in the FDA AER plate

Signature read: Thyroid gland disorder NOS's 27.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 50 of 185 reports (27.0% of named reports). Nearest volume peer: Coughing up blood (±0 reports). Lead species Dog (142). Lead co-reported drug Milbemycin Oxime + Spinosad (36).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 142
Cat 38
Human 4
Horse 1

Breeds Most Affected

Domestic Shorthair 23
Retriever - Labrador 18
Boxer (German Boxer) 10
Chihuahua 10
Terrier - Boston 9
Retriever - Golden 8
Dog (unknown) 8
Domestic Longhair 6
Maltese 6
Beagle 5

Associated Drugs

Milbemycin Oxime + Spinosad 36
Oclacitinib Maleate 22
Spinosad 20
Trilostane 15
Carprofen 10
Maropitant Citrate 10
Imidacloprid + Moxidectin 7
Selamectin 7
Fluralaner Chew Tablets 7
Afoxolaner 6
Levothyroxine Sodium 5
Telmisartan 5
Moxidectin 4
Vitamin B12 4
Enrofloxacin 4
Ivermectin 4
Ivermectin + Pyrantel As Pamoate Salt 4
Fluralaner 13.64% 12-Week Chew 4
Cefovecin 3
Meloxicam 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Thyroid gland disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Thyroid gland disorder NOS (#1079 of 2,481 by report volume); death-coded 27.0%. PlainBreed reaction plate · death-coded share stamp 27.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →