Reaction profile

The FDA adverse-event record for lymphadenopathy

928 FDA reports name lymphadenopathy, a high-volume reaction in the CVM extract (VeDDRA 174). Plate stamps and neighbourhood peers follow.

#416 of 2,481
by report volume (all reactions)
928
reports citing this reaction
27.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lymphadenopathy has 928 reports now versus 910 in that prior snapshot: 18 more (2.0%).

Report change
+18
Death-coded reports
+3
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lymphadenopathy changes

FDA AER · VeDDRA plate

Code 174 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 928 reports
  • DEATH-HOT 27.0%
  • UPPER-Q #416/2481
  • PHOTO-FINISH Lip licking
  • SPECIES-DOG Dog · 791
  • DRUG-LEAD Oclacitinib Malea… · 174
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Lip licking (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lymphadenopathy

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lip licking · near928Lymphadenopathy · this react…928Hyperalbuminaemia · near927Reduced responses · near924Knuckling · near923Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lymphadenopathy

Lymphadenopathy: high death-coded share in the FDA AER plate

Signature read: 251 death-coded reports is a heavy tail count for Lymphadenopathy in the CVM extract. Report volume is upper-third scale: 928 named reports in the openFDA extract. Death-coded share is upper-third: 251 of 928 reports (27.0% of named reports). Nearest volume peer: Lip licking (±0 reports). Lead species Dog (791). Lead co-reported drug Oclacitinib Maleate (174).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 791
Cat 121
Cattle 9
Horse 4
Human 1
Pig 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 94
Domestic Shorthair 54
Crossbred Canine/dog 46
Retriever - Golden 42
Shepherd Dog - German 41
Boxer (German Boxer) 32
Domestic (unspecified) 28
Shih Tzu 27
Terrier - Bull - American Pit 27
Terrier - Yorkshire 17

Associated Drugs

Oclacitinib Maleate 174
Carprofen 103
Maropitant Citrate 80
Milbemycin Oxime + Spinosad 68
Cyclosporine A 57
Cyclosporine 54
Bedinvetmab 51
Prednisone 45
Afoxolaner 44
Gabapentin 42
Moxidectin 40
Deracoxib 39
Enrofloxacin 38
Robenacoxib 28
Cephalexin 28
Doxycycline 28
Famotidine 26
Anti-Il31 Mab Mcs Lot #1283563 26
Spinosad 25
Buprenorphine 25

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lymphadenopathy, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (928 here).

Similar death-coded share

Nearest other reactions by death-coded share (27.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lymphadenopathy (#416 of 2,481 by report volume); death-coded 27.0%. PlainBreed reaction plate · death-coded report count stamp 251 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →