Reaction profile

The FDA adverse-event record for peripheral nervous system disorder nos

183 FDA adverse-event reports reference peripheral nervous system disorder nos (VeDDRA 1906). See the species, breeds, and drugs most associated with it below.

183
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
183
Total Reports
50
Deaths
27.3%
Death Rate

Species Most Affected

Dog 109
Cat 64
Horse 5
Human 3
Turtle 1
Mouse 1

Breeds Most Affected

Domestic (unspecified) 57
Crossbred Canine/dog 16
Dog (unknown) 8
Retriever - Golden 7
Retriever - Labrador 7
Mastiff 6
Unknown 4
Pointing Dog - German Short-haired 4
Rottweiler 4
Boxer (German Boxer) 3

Associated Drugs

Spinosad 15
Selamectin 14
Cefovecin Sodium 14
Human Insulin 12
Carprofen 12
Ivermectin 8
Meloxicam 7
Amoxicillin, Clavulanate 6
Firocoxib 6
Dexmedetomidine Hydrochloride 5
Isoflurane 4
Ketamine Hydrochloride 4
Cefpodoxime Proxetil 4
Milbemycin, Lufenuron 4
Marbofloxacin 4
Maropitant 4
Milbemycin 4
Imidacloprid, Moxidectin 3
Orbifloxacin 3
Tiletamine, Zolazepam 3

Peripheral nervous system disorder NOS Reaction Insights

183 reports name Peripheral nervous system disorder NOS; 50 recorded a death outcome (27.3% of reported events, not a population-level mortality rate). VeDDRA code: 1906.

By species: Dog (109 reports), Cat (64 reports), Horse (5 reports). By breed: Domestic (unspecified) (57), Crossbred Canine/dog (16), Dog (unknown) (8).

Most co-reported drugs: Spinosad (15 reports), Selamectin (14 reports), Cefovecin Sodium (14 reports), Human Insulin (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.