Reaction profile

The FDA adverse-event record for coughing up blood

177 FDA adverse-event reports reference coughing up blood (VeDDRA 1970). See the species, breeds, and drugs most associated with it below.

177
reports citing this reaction
32.8%
death-coded share
Dog
most-affected species
Melarsomine Dihydrochloride
most-associated drug
Verify with FDA CVM →
177
Total Reports
58
Deaths
32.8%
Death Rate

Species Most Affected

Dog 169
Cat 4
Other Equids 2
Cattle 1
Human 1

Breeds Most Affected

Retriever - Labrador 20
Pit Bull 12
Shih Tzu 11
Chihuahua 11
Boxer (German Boxer) 8
Dog (unknown) 6
Crossbred Canine/dog 6
Retriever - Golden 5
Terrier - Bull - American Pit 5
Mixed (Dog) 4

Associated Drugs

Melarsomine Dihydrochloride 26
Milbemycin Oxime + Spinosad 21
Maropitant Citrate 16
Doxycycline 15
Carprofen 14
Ivermectin + Pyrantel As Pamoate Salt 13
Moxidectin 13
Melarsomine Dihydrochloride Injection 12
Prednisone 10
Furosemide 8
Spinosad 8
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 7
Melarsomine Dihydrocloride Injectable 25Mg/Ml 6
Butorphanol 6
Oclacitinib Maleate 6
Milbemycin Oxime 6
Dexamethasone 6
Pimobendan 5
Afoxolaner 5
Milbemycin Oxime + Praziquantel 5

Coughing up blood Reaction Insights

177 reports name Coughing up blood; 58 recorded a death outcome (32.8% of reported events, not a population-level mortality rate). VeDDRA code: 1970.

By species: Dog (169 reports), Cat (4 reports), Other Equids (2 reports). By breed: Retriever - Labrador (20), Pit Bull (12), Shih Tzu (11).

Most co-reported drugs: Melarsomine Dihydrochloride (26 reports), Milbemycin Oxime + Spinosad (21 reports), Maropitant Citrate (16 reports), Doxycycline (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.