Reaction profile

The FDA adverse-event record for heart block nos

124 FDA adverse-event reports reference heart block nos (VeDDRA 191). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1288 of 2,481
by report volume (all reactions)
124
reports citing this reaction
10.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Heart block NOS has 124 reports now versus 122 in that prior snapshot: 2 more (1.6%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Heart block NOS changes

FDA AER · VeDDRA plate

Code 191 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 124 reports
  • DEATH-ELEV 10.5%
  • MID-PACK #1288/2481
  • PHOTO-FINISH Thrombosis
  • SPECIES-DOG Dog · 116
  • DRUG-LEAD Dexmedetomidine H… · 45
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Thrombosis (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Heart block NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Generalised red spot · near125Heart block NOS · this react…124Thrombosis · near124Birth defect · near123Hypomagnesaemic condi… · near123Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Heart block NOS

What the FDA AER plate says about Heart block NOS

Signature read: death-coded share at 10.5% is the most distinctive outcome stamp on Heart block NOS. Report volume sits in the middle third of the reaction corpus. 13 of 124 reports were death-coded (10.5% of named reports, not a population mortality rate). Nearest volume peer: Thrombosis (±0 reports). Lead species Dog (116). Lead co-reported drug Dexmedetomidine Hydrochloride (45).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Dexmedetomidine Hydrochloride appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 116
Cat 7
Human 1

Breeds Most Affected

Dog (unknown) 20
Retriever - Labrador 8
Shepherd Dog - Australian 7
Unknown 7
Retriever - Golden 5
Shepherd Dog - German 4
Schnauzer - Miniature 3
Boxer (German Boxer) 3
Domestic Shorthair 3
Chihuahua 3

Associated Drugs

Dexmedetomidine Hydrochloride 45
Propofol 35
Isoflurane 29
Butorphanol 20
Milbemycin Oxime + Spinosad 15
Maropitant Citrate 14
Sevoflurane 9
Dexmedetomidine 8
Butorphanol Tartrate 8
Buprenorphine 7
Hydromorphone Hcl Injectable 6
Carprofen 5
Atropine 5
Atipamezole Hydrochloride 5
Acepromazine 5
Atipamezole 5
Meloxicam 4
Acepromazine Maleate 4
Midazolam 4
Anesthetic 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Heart block NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (124 here).

Similar death-coded share

Nearest other reactions by death-coded share (10.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Heart block NOS (#1288 of 2,481 by report volume); death-coded 10.5%. PlainBreed reaction plate · death-coded share stamp 10.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →