Reaction profile

The FDA adverse-event record for hypomagnesaemic condition

113 FDA adverse-event reports reference hypomagnesaemic condition (VeDDRA 564). See the species, breeds, and drugs most associated with it below.

113
reports citing this reaction
23.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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113
Total Reports
27
Deaths
23.9%
Death Rate

Species Most Affected

Dog 93
Cat 9
Cattle 7
Horse 3
Human 1

Breeds Most Affected

Retriever - Labrador 8
Crossbred Canine/dog 8
Domestic Shorthair 6
Shih Tzu 5
Retriever - Golden 4
Mastiff 3
Terrier - Tibetan 3
Holstein-Friesian also known as Holstein 3
Terrier - Cairn 3
Dachshund - Miniature 3

Associated Drugs

Milbemycin Oxime + Spinosad 18
Trilostane 11
Oclacitinib Maleate 8
Cyclosporine 6
Ivermectin + Pyrantel As Pamoate Salt 6
Spinosad 5
Carprofen 4
Milbemycin Oxime 4
Maropitant Citrate 4
Meloxicam 4
Fluralaner Chew Tablets 4
Afoxolaner 4
Velagliflozin Proline Monohydrate 4
Vaccines (Unknown) 3
Enrofloxacin 3
Sucralfate 3
Toceranib Phosphate 3
Monensin Sodium 3
Melarsomine Dihydrochloride 2
Selamectin 2

Hypomagnesaemic condition Reaction Insights

113 reports name Hypomagnesaemic condition; 27 recorded a death outcome (23.9% of reported events, not a population-level mortality rate). VeDDRA code: 564.

By species: Dog (93 reports), Cat (9 reports), Cattle (7 reports). By breed: Retriever - Labrador (8), Crossbred Canine/dog (8), Domestic Shorthair (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (18 reports), Trilostane (11 reports), Oclacitinib Maleate (8 reports), Cyclosporine (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.