Reaction profile

The FDA adverse-event record for thrombocytosis

1,385 FDA adverse-event reports reference thrombocytosis (VeDDRA 2116). See the species, breeds, and drugs most associated with it below.

1,385
reports citing this reaction
16.3%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
1,385
Total Reports
226
Deaths
16.3%
Death Rate

Species Most Affected

Dog 1,325
Cat 56
Other Canids 1
Cattle 1
Horse 1
Wolf 1

Breeds Most Affected

Chihuahua 113
Shih Tzu 110
Retriever - Labrador 72
Crossbred Canine/dog 68
Maltese 63
Terrier - Yorkshire 49
Terrier - Boston 47
Terrier (unspecified) 39
Beagle 37
Domestic Shorthair 30

Associated Drugs

Trilostane 596
Milbemycin Oxime + Spinosad 113
Carprofen 97
Oclacitinib Maleate 84
Afoxolaner 71
Spinosad 70
Bedinvetmab 67
Maropitant Citrate 64
Fluralaner Chew Tablets 64
Gabapentin 64
Grapiprant 53
Ivermectin + Pyrantel As Pamoate Salt 49
Meloxicam 46
Cyclosporine 45
Prednisone 43
Milbemycin Oxime + Praziquantel 33
Pimobendan 30
Polysulfated Glycosaminoglycan 29
Fluralaner 13.64% 12-Week Chew 28
Deracoxib 27

Thrombocytosis Reaction Insights

1,385 reports name Thrombocytosis; 226 recorded a death outcome (16.3% of reported events, not a population-level mortality rate). VeDDRA code: 2116.

By species: Dog (1,325 reports), Cat (56 reports), Other Canids (1 reports). By breed: Chihuahua (113), Shih Tzu (110), Retriever - Labrador (72).

Most co-reported drugs: Trilostane (596 reports), Milbemycin Oxime + Spinosad (113 reports), Carprofen (97 reports), Oclacitinib Maleate (84 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.