Reaction profile

The FDA adverse-event record for oral cavity disorder nos

461 FDA adverse-event reports reference oral cavity disorder nos (VeDDRA 2229). See the species, breeds, and drugs most associated with it below.

461
reports citing this reaction
16.1%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
461
Total Reports
74
Deaths
16.1%
Death Rate

Species Most Affected

Dog 319
Cat 92
Horse 24
Human 17
Chicken 2
Rabbit 2
Cattle 2
Pig 2
Donkey 1

Breeds Most Affected

Domestic Shorthair 48
Retriever - Labrador 28
Unknown 18
Chihuahua 18
Retriever - Golden 18
Crossbred Canine/dog 13
Boxer (German Boxer) 12
Shih Tzu 12
Terrier - Yorkshire 11
Shepherd Dog - German 11

Associated Drugs

Oclacitinib Maleate 60
Milbemycin Oxime + Spinosad 50
Afoxolaner 28
Carprofen 23
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 21
Maropitant Citrate 21
Ivermectin + Pyrantel As Pamoate Salt 20
Cefovecin 16
Bedinvetmab 16
Moxidectin 15
Spinosad 14
Milbemycin Oxime + Praziquantel 14
Gabapentin 13
Cyclosporine 13
Anti-Il31 Mab Mcs Lot #1283563 13
Prednisone 13
Trilostane 12
Selamectin 12
Robenacoxib 12
Doxycycline 12

Oral cavity disorder NOS Reaction Insights

461 reports name Oral cavity disorder NOS; 74 recorded a death outcome (16.1% of reported events, not a population-level mortality rate). VeDDRA code: 2229.

By species: Dog (319 reports), Cat (92 reports), Horse (24 reports). By breed: Domestic Shorthair (48), Retriever - Labrador (28), Unknown (18).

Most co-reported drugs: Oclacitinib Maleate (60 reports), Milbemycin Oxime + Spinosad (50 reports), Afoxolaner (28 reports), Carprofen (23 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.