Reaction profile

The FDA adverse-event record for allergic reaction

1,528 FDA reports name allergic reaction, a high-volume reaction in the CVM extract (VeDDRA 1304). Plate stamps and neighbourhood peers follow.

#283 of 2,481
by report volume (all reactions)
1,528
reports citing this reaction
3.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Allergic reaction has 1,528 reports now versus 1,510 in that prior snapshot: 18 more (1.2%).

Report change
+18
Death-coded reports
+1
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Allergic reaction changes

FDA AER · VeDDRA plate

Code 1304 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,528 reports
  • DEATH-LOW 3.0%
  • UPPER-Q #283/2481
  • PHOTO-FINISH Thrombocytosis
  • SPECIES-DOG Dog · 1,375
  • DRUG-LEAD Moxidectin · 605
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Thrombocytosis (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Allergic reaction

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Increased respiratory… · near1534Contamination, Foreig… · near1531Staring · near1531Thrombocytosis · near1529Allergic reaction · this rea…1528Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Allergic reaction

Allergic reaction: low death-coded share in the FDA AER plate

Signature read: 1,528 reports place Allergic reaction in the upper third of FDA AER volume (#283 of 2,481). Report volume is upper-third scale: 1,528 named reports in the openFDA extract. Death-coded share is lower-third: 46 of 1,528 reports (3.0% of named reports). Nearest volume peer: Thrombocytosis (±1 reports). Lead species Dog (1,375). Lead co-reported drug Moxidectin (605).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,375
Cat 61
Human 43
Horse 22
Cattle 18
Unknown 5
Pig 2
Ferret 1
Other 1

Breeds Most Affected

Retriever - Labrador 113
Terrier - Bull - American Pit 94
Dog (unknown) 91
Chihuahua 87
Boxer (German Boxer) 70
Crossbred Canine/dog 54
Unknown 53
Dachshund (unspecified) 43
Terrier - Yorkshire 42
Shih Tzu 42

Associated Drugs

Moxidectin 605
Afoxolaner 159
Rabies Virus, 96
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 92
Fluralaner Chew Tablets 89
Milbemycin Oxime + Spinosad 81
Maropitant Citrate 70
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 52
Diphenhydramine Hcl 45
Ivermectin + Pyrantel As Pamoate Salt 40
Pyrantel Pamoate;Sarolaner 39
Oclacitinib Maleate 37
Prednisone 33
Carprofen 33
Anti-Il31 Mab Mcs Lot #1283563 31
Milbemycin Oxime + Praziquantel 31
Spinosad 28
Polysulfated Glycosaminoglycan 28
Diphenhydramine 27
Cefovecin 27

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Allergic reaction, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,528 here).

Similar death-coded share

Nearest other reactions by death-coded share (3.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Allergic reaction (#283 of 2,481 by report volume); death-coded 3.0%. PlainBreed reaction plate · report volume stamp 1,528 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →