Reaction profile

The FDA adverse-event record for tense muscles

199 FDA adverse-event reports reference tense muscles (VeDDRA 2248). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1040 of 2,481
by report volume (all reactions)
199
reports citing this reaction
7.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Tense muscles has 199 reports now versus 186 in that prior snapshot: 13 more (7.0%).

Report change
+13
Death-coded reports
+2
Death-coded share
+0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Tense muscles changes

FDA AER · VeDDRA plate

Code 2248 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 199 reports
  • DEATH-PAR 7.5%
  • MID-PACK #1040/2481
  • PHOTO-FINISH Anal and rectal disor…
  • SPECIES-DOG Dog · 181
  • DRUG-LEAD Afoxolaner · 23
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Anal and rectal disorder NOS (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Tense muscles

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Anal and rectal disor… · near199Calculi · near199Eye itching · near199Harsh lung sounds · near199Tense muscles · this reaction199Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Tense muscles

Tense muscles: low death-coded share in the FDA AER plate

Signature read: Tense muscles's 7.5% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 15 of 199 reports (7.5% of named reports). Nearest volume peer: Anal and rectal disorder NOS (±0 reports). Lead species Dog (181). Lead co-reported drug Afoxolaner (23).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 181
Cat 12
Horse 4
Goat 1
Other Equids 1

Breeds Most Affected

Retriever - Labrador 19
Crossbred Canine/dog 16
Chihuahua 14
Terrier (unspecified) 10
Domestic Shorthair 8
Shih Tzu 8
Retriever - Golden 7
Boxer (German Boxer) 7
Bulldog - French 6
Dachshund (unspecified) 5

Associated Drugs

Afoxolaner 23
Fluralaner Chew Tablets 23
Fluralaner 13.64% 12-Week Chew 18
Bedinvetmab 17
Milbemycin Oxime + Spinosad 12
Carprofen 12
Oclacitinib Maleate 12
Pyrantel Pamoate;Sarolaner 12
Ivermectin + Pyrantel As Pamoate Salt 11
Sarolaner 10
Gabapentin 9
Maropitant Citrate 6
Moxidectin 6
Propofol 6
Prednisone 5
Nitenpyram 5
Methocarbamol 5
Fluralaner Spot-On Solution 5
Diphenhydramine 5
Cefovecin 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Tense muscles, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (199 here).

Similar death-coded share

Nearest other reactions by death-coded share (7.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Tense muscles (#1040 of 2,481 by report volume); death-coded 7.5%. PlainBreed reaction plate · death-coded share stamp 7.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →