Reaction profile

The FDA adverse-event record for generalised allergic reaction nos

133 FDA adverse-event reports reference generalised allergic reaction nos (VeDDRA 1115). See the species, breeds, and drugs most associated with it below.

133
reports citing this reaction
7.5%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
133
Total Reports
10
Deaths
7.5%
Death Rate

Species Most Affected

Dog 108
Cattle 9
Cat 7
Human 5
Horse 4

Breeds Most Affected

Retriever - Labrador 10
Chihuahua 7
Dog (unknown) 7
Unknown 6
Shih Tzu 5
Dachshund (unspecified) 5
Crossbred Canine/dog 4
Bulldog - French 4
Pit Bull 4
Holstein-Friesian also known as Holstein 3

Associated Drugs

Moxidectin 16
Desoxycorticosterone Pivalate 15
Lufenuron + Milbemycin Oxime 14
Cyclosporine A 13
Prednisone 10
Nitenpyram 9
Buprenorphine 3
Milbemycin Oxime 3
Carprofen 3
Polysulfated Glycosaminoglycan 3
Deracoxib 3
Grapiprant 3
Rabies Virus, 3
Trimeprazine/Prednisolone 2
Fipronil, Cyphenothrin 2
Dexamethasone 2
Doxycycline 2
Triamcinolone Acetonide 2
Imidacloprid 2
Cefovecin 2

Generalised allergic reaction NOS Reaction Insights

133 reports name Generalised allergic reaction NOS; 10 recorded a death outcome (7.5% of reported events, not a population-level mortality rate). VeDDRA code: 1115.

By species: Dog (108 reports), Cattle (9 reports), Cat (7 reports). By breed: Retriever - Labrador (10), Chihuahua (7), Dog (unknown) (7).

Most co-reported drugs: Moxidectin (16 reports), Desoxycorticosterone Pivalate (15 reports), Lufenuron + Milbemycin Oxime (14 reports), Cyclosporine A (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.