Reaction profile

The FDA adverse-event record for skin inflammation nos

993 FDA reports name skin inflammation nos, a high-volume reaction in the CVM extract (VeDDRA 1759). Plate stamps and neighbourhood peers follow.

#395 of 2,481
by report volume (all reactions)
993
reports citing this reaction
3.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Skin inflammation NOS has 993 reports now versus 974 in that prior snapshot: 19 more (2.0%).

Report change
+19
Death-coded reports
+1
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Skin inflammation NOS changes

FDA AER · VeDDRA plate

Code 1759 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 993 reports
  • DEATH-LOW 3.3%
  • UPPER-Q #395/2481
  • PHOTO-FINISH Abnormal menace refle…
  • SPECIES-DOG Dog · 827
  • DRUG-LEAD Milbemycin Oxime… · 125
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal menace reflex test (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Skin inflammation NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lack of efficacy (hea… · near1001Abnormal menace refle… · near993Skin inflammation NOS · this…993Eosinopenia · near991Lack of efficacy (tap… · near990Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Skin inflammation NOS

Skin inflammation NOS: low death-coded share in the FDA AER plate

Signature read: 993 reports place Skin inflammation NOS in the upper third of FDA AER volume (#395 of 2,481). Report volume is upper-third scale: 993 named reports in the openFDA extract. Death-coded share is lower-third: 33 of 993 reports (3.3% of named reports). Nearest volume peer: Abnormal menace reflex test (±0 reports). Lead species Dog (827). Lead co-reported drug Milbemycin Oxime + Spinosad (125).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 827
Cat 143
Human 9
Horse 6
Cattle 4
Pig 1
Ferret 1
Unknown 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 92
Retriever - Labrador 90
Crossbred Canine/dog 46
Chihuahua 41
Shepherd Dog - German 37
Retriever - Golden 31
Terrier - Yorkshire 29
Terrier - Bull - American Pit 26
Dog (unknown) 24
Bulldog 23

Associated Drugs

Milbemycin Oxime + Spinosad 125
Oclacitinib Maleate 113
Afoxolaner 80
Carprofen 52
Prednisone 50
Selamectin 48
Moxidectin 44
Imidacloprid + Moxidectin 43
Spinosad 35
Fluralaner Chew Tablets 35
Maropitant Citrate 32
Anti-Il31 Mab Mcs Lot #1283563 32
Diphenhydramine 29
Trilostane 29
Cefovecin 29
Gabapentin 28
Pyrantel Pamoate;Sarolaner 28
Frunevetmab 27
Bedinvetmab 27
Cyclosporine 21

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Skin inflammation NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (3.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Skin inflammation NOS (#395 of 2,481 by report volume); death-coded 3.3%. PlainBreed reaction plate · report volume stamp 993 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →