Reaction profile

The FDA adverse-event record for skin inflammation nos

941 FDA adverse-event reports reference skin inflammation nos (VeDDRA 1759). See the species, breeds, and drugs most associated with it below.

941
reports citing this reaction
3.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
941
Total Reports
31
Deaths
3.3%
Death Rate

Species Most Affected

Dog 783
Cat 136
Human 9
Horse 6
Cattle 3
Pig 1
Ferret 1
Rabbit 1
Unknown 1

Breeds Most Affected

Domestic Shorthair 90
Retriever - Labrador 88
Crossbred Canine/dog 43
Chihuahua 38
Shepherd Dog - German 37
Retriever - Golden 31
Terrier - Yorkshire 29
Dog (unknown) 23
Bulldog 23
Shih Tzu 21

Associated Drugs

Milbemycin Oxime + Spinosad 125
Oclacitinib Maleate 99
Afoxolaner 76
Carprofen 50
Selamectin 48
Imidacloprid + Moxidectin 43
Prednisone 42
Moxidectin 42
Spinosad 35
Fluralaner Chew Tablets 35
Cefovecin 28
Trilostane 26
Anti-Il31 Mab Mcs Lot #1283563 26
Bedinvetmab 25
Maropitant Citrate 24
Frunevetmab 24
Pyrantel Pamoate;Sarolaner 23
Diphenhydramine 20
Ivermectin + Pyrantel As Pamoate Salt 20
Gabapentin 20

Skin inflammation NOS Reaction Insights

941 reports name Skin inflammation NOS; 31 recorded a death outcome (3.3% of reported events, not a population-level mortality rate). VeDDRA code: 1759.

By species: Dog (783 reports), Cat (136 reports), Human (9 reports). By breed: Domestic Shorthair (90), Retriever - Labrador (88), Crossbred Canine/dog (43).

Most co-reported drugs: Milbemycin Oxime + Spinosad (125 reports), Oclacitinib Maleate (99 reports), Afoxolaner (76 reports), Carprofen (50 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.