Reaction profile

The FDA adverse-event record for lack of efficacy (tapeworm)

990 FDA adverse-event reports reference lack of efficacy (tapeworm) (VeDDRA 2657). See the species, breeds, and drugs most associated with it below.

990
reports citing this reaction
0.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Praziquantel
most-associated drug
Verify with FDA CVM →
990
Total Reports
2
Deaths
0.2%
Death Rate

Species Most Affected

Dog 879
Cat 104
Cattle 6
Horse 1

Breeds Most Affected

Retriever - Labrador 139
Domestic Shorthair 61
Crossbred Canine/dog 60
Retriever - Golden 56
Dog (unknown) 47
Shepherd Dog - German 31
Beagle 27
Chihuahua 25
Terrier - Yorkshire 24
Spitz - German Pomeranian 23

Associated Drugs

Milbemycin Oxime + Praziquantel 511
Milbemycin Oxime + Spinosad 110
Ivermectin + Pyrantel As Pamoate Salt 105
Afoxolaner 91
Praziquantel 67
Lufenuron + Milbemycin Oxime + Praziquantel 46
Emodepside + Praziquantel 40
Fluralaner 35
Sarolaner 34
Milbemycin Oxime 30
Milbemcyin Oxime, Lufenuron, Praziquantel 25
Lotilaner 24
Moxidectin 22
Lufenuron + Milbemycin Oxime 21
Epsiprantel 19
Praziquantel + Pyrantel Pamoate 19
Selamectin 18
Imidacloprid + Pyriproxyfen 16
Imidacloprid + Moxidectin 12
Spinetoram 11

Lack of efficacy (tapeworm) Reaction Insights

990 reports name Lack of efficacy (tapeworm); 2 recorded a death outcome (0.2% of reported events, not a population-level mortality rate). VeDDRA code: 2657.

By species: Dog (879 reports), Cat (104 reports), Cattle (6 reports). By breed: Retriever - Labrador (139), Domestic Shorthair (61), Crossbred Canine/dog (60).

Most co-reported drugs: Milbemycin Oxime + Praziquantel (511 reports), Milbemycin Oxime + Spinosad (110 reports), Ivermectin + Pyrantel As Pamoate Salt (105 reports), Afoxolaner (91 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.