Reaction profile

The FDA adverse-event record for rough recovery

91 FDA adverse-event reports reference rough recovery (VeDDRA 2503). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1441 of 2,481
by report volume (all reactions)
91
reports citing this reaction
14.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Rough recovery has 91 reports now versus 88 in that prior snapshot: 3 more (3.4%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Rough recovery changes

FDA AER · VeDDRA plate

Code 2503 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 91 reports
  • DEATH-ELEV 14.3%
  • MID-PACK #1441/2481
  • PHOTO-FINISH Application site pyod…
  • SPECIES-DOG Dog · 49
  • DRUG-LEAD Ketamine Hydrochl… · 28
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site pyoderma (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Rough recovery

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site pyod… · near91Gastric volvulus · near91Pemphigus foliaceus · near91Rough recovery · this reacti…91Sensory abnormality N… · near91Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Rough recovery

What the FDA AER plate says about Rough recovery

Signature read: report volume at 91 (#1441 of 2,481) is the standout scale stamp on Rough recovery. Report volume sits in the middle third of the reaction corpus. 13 of 91 reports were death-coded (14.3% of named reports, not a population mortality rate). Nearest volume peer: Application site pyoderma (±0 reports). Lead species Dog (49). Lead co-reported drug Ketamine Hydrochloride (28).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ketamine Hydrochloride appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 49
Cat 21
Horse 18
Cattle 2
Monkey 1

Breeds Most Affected

Domestic Shorthair 11
Dog (unknown) 8
Horse (unknown) 8
Quarter Horse 6
Chihuahua 5
Cat (unknown) 4
Mixed (Dog) 3
Retriever - Labrador 3
Unknown 3
Shepherd Dog - German 3

Associated Drugs

Ketamine Hydrochloride 28
Isoflurane 22
Dexmedetomidine 17
Alfaxalone 15
Butorphanol 12
Buprenorphine 12
Ketamine 10
Carprofen 10
Dexmedetomidine Hydrochloride 8
Propofol 7
Atipamezole 6
Butorphanol Tartrate 5
Acepromazine 5
Midazolam 5
Xylazine Hydrochloride 5
Atropine 4
Atipamezole Hydrochloride 4
Diazepam 4
Isoflurane Gas 3
Morphine 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Rough recovery, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (91 here).

Similar death-coded share

Nearest other reactions by death-coded share (14.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Rough recovery (#1441 of 2,481 by report volume); death-coded 14.3%. PlainBreed reaction plate · report volume stamp 91 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →