Reaction profile

The FDA adverse-event record for application site pyoderma

89 FDA adverse-event reports reference application site pyoderma (VeDDRA 28). See the species, breeds, and drugs most associated with it below.

89
reports citing this reaction
2.2%
death-coded share
Cat
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
89
Total Reports
2
Deaths
2.2%
Death Rate

Species Most Affected

Cat 55
Dog 33
Cattle 1

Breeds Most Affected

Domestic Shorthair 35
Domestic Mediumhair 10
Retriever - Golden 6
Domestic Longhair 5
Retriever - Labrador 5
Mixed (Dog) 3
Rottweiler 2
Crossbred Canine/dog 2
Doberman Pinscher 1
Bloodhound 1

Associated Drugs

Imidacloprid + Moxidectin 29
Emodepside + Praziquantel 14
Flumethrin-Imidacloprid 11
Selamectin 10
Rabies Vaccine 6
Buprenorphine 5
Chlorhexidine Gluconate + Climbazole + Phytosphingosine Salicyloyl 4
Selamectin;Sarolaner 4
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 3
Fipronil 10%/S Methoprene 9% Spot On 3
Praziquantel + Pyrantel 3
Nitenpyram 3
Cefovecin 3
Methylprednisolone Acetate 3
Prednisolone 3
Praziquantel 2
Dexamethasone 2
Rabies 2
Prednisone 2
Penicillin 2

Application site pyoderma Reaction Insights

89 reports name Application site pyoderma; 2 recorded a death outcome (2.2% of reported events, not a population-level mortality rate). VeDDRA code: 28.

By species: Cat (55 reports), Dog (33 reports), Cattle (1 reports). By breed: Domestic Shorthair (35), Domestic Mediumhair (10), Retriever - Golden (6).

Most co-reported drugs: Imidacloprid + Moxidectin (29 reports), Emodepside + Praziquantel (14 reports), Flumethrin-Imidacloprid (11 reports), Selamectin (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.