Reaction profile

The FDA adverse-event record for respiratory signs

467 FDA adverse-event reports reference respiratory signs (VeDDRA 1181). See the species, breeds, and drugs most associated with it below.

467
reports citing this reaction
45.8%
death-coded share
Dog
most-affected species
Monensin Sodium
most-associated drug
Verify with FDA CVM →
467
Total Reports
214
Deaths
45.8%
Death Rate

Species Most Affected

Dog 206
Cattle 147
Cat 92
Pig 9
Horse 6
Human 5
Chicken 2

Breeds Most Affected

Domestic Shorthair 52
Cattle (other) 37
Holstein-Friesian also known as Holstein 26
Crossbred Bovine/Cattle 23
Retriever - Labrador 22
Cattle (unknown) 16
Aberdeen Angus 15
Mixed (Cattle) 14
Chihuahua 11
Pug 11

Associated Drugs

Monensin Sodium 38
Moxidectin 31
Milbemycin Oxime + Spinosad 30
Maropitant Citrate 28
Cefovecin 25
Enrofloxacin 21
Bovine Virus*5/Past M+Mh Lv/Lb 20
Oclacitinib Maleate 17
Carprofen 16
Fenbendazol Suspension 15
Prednisone 14
Tylosin Phosphate 13
Dexmedetomidine Hydrochloride 13
Tildipirosin Injectable 13
Selamectin 13
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid 13
Famotidine 12
Florfenicol/Flunixin Inj-Triac 12
Fluralaner Chew Tablets 12
Imidacloprid + Moxidectin 11

Respiratory signs Reaction Insights

467 reports name Respiratory signs; 214 recorded a death outcome (45.8% of reported events, not a population-level mortality rate). VeDDRA code: 1181.

By species: Dog (206 reports), Cattle (147 reports), Cat (92 reports). By breed: Domestic Shorthair (52), Cattle (other) (37), Holstein-Friesian also known as Holstein (26).

Most co-reported drugs: Monensin Sodium (38 reports), Moxidectin (31 reports), Milbemycin Oxime + Spinosad (30 reports), Maropitant Citrate (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.